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1. (WO1997036606) CONSTRAINED CD4 PEPTIDES AND METHODS OF USING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/036606    International Application No.:    PCT/US1997/004847
Publication Date: 09.10.1997 International Filing Date: 25.03.1997
Chapter 2 Demand Filed:    29.10.1997    
IPC:
A61K 38/00 (2006.01), C07K 14/73 (2006.01)
Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; Suite 300, 3700 Market Street, Philadelphia, PA 19104 (US) (For All Designated States Except US).
GREENE, Mark, I. [US/US]; (US) (For US Only).
ZHANG, Xin [CN/US]; (US) (For US Only)
Inventors: GREENE, Mark, I.; (US).
ZHANG, Xin; (US)
Agent: ELDERKIN, Dianne, B.; Woodcock Washburn Kurtz Mackiewicz & Norris L.L.P., 46th floor, One Liberty Place, Philadelphia, PA 19103 (US)
Priority Data:
60/014,294 29.03.1996 US
Title (EN) CONSTRAINED CD4 PEPTIDES AND METHODS OF USING THE SAME
(FR) PEPTIDES CONTRAINTS A SEQUENCE DE CD4 ET PROCEDES D'UTILISATION ASSOCIES
Abstract: front page image
(EN)Constrained peptides comprising an amino acid sequence that consists of 30 amino acid residues or less are disclosed. The peptides comprise a human CD4 sequence within a cyclic portion and two exocyclic portions, which each comprises an aromatic amino acid residue, are disclosed. Pharmaceutical compositions comprising the peptide are disclosed. Methods of inhibiting the oligomerization of membrane bound CD4 in a CD4+ cell by contacting the cell with a peptide are disclosed. Methods of inhibiting activation of a T cell and methods of treating individuals with diseases, disorders and conditions whose causes and/or symptoms are associated with and/or characterized by T cell activation are disclosed.
(FR)Cette invention concerne des peptides contraints comportant une séquence d'acides aminés constituée d'au plus 30 résidus d'acides aminés. Ces peptides comporte une séquence de CD4 d'origine humaine à l'intérieur d'une partie cyclique ainsi que deux parties exocycliques comportant chacune un résidu d'acide aminé aromatique. Cette invention concerne également des compositions pharmaceutiques contenant ledit peptide ainsi que des procédés permettant d'inhiber l'oligomérisation de CD4 lié à la membrane dans une cellule de CD4+ et consistant à mettre en contact la cellule avec un peptide. L'invention concerne en outre des procédés permettant d'inhiber l'activation d'un lymphocyte T ainsi que des procédés de traitement d'individus souffrant de maladies, de troubles ou d'états pathologiques dont les causes ou les symptômes sont liés à (et/ou caractérisés par) l'activation des lymphocytes T.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)