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1. (WO1997036605) INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/036605 International Application No.: PCT/US1997/004713
Publication Date: 09.10.1997 International Filing Date: 27.03.1997
Chapter 2 Demand Filed: 24.10.1997
IPC:
C07D 401/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
GRAHAM, Samuel, L. [US/US]; US (UsOnly)
WILLIAMS, Theresa, M. [US/US]; US (UsOnly)
WAI, John, S. [GB/US]; US (UsOnly)
Inventors:
GRAHAM, Samuel, L.; US
WILLIAMS, Theresa, M.; US
WAI, John, S.; US
Agent:
MUTHARD, David, A.; Merck & Co., Inc. Patent Dept. 126 East Lincoln Avenue Rahway, NJ 07065, US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/014,79303.04.1996US
9609667.209.05.1996GB
Title (EN) INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
(FR) INHIBITEURS DE FARNESYL-PROTEINE TRANSFERASE
Abstract:
(EN) The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
(FR) L'invention concerne des composés qui inhibent la farnésyl-protéine transférase (FTase) et la farnésylation de la protéine Ras oncogène. L'invention a en outre pour objet des compositions chimiothérapeutiques contenant les composés de cette invention et des procédés pour inhiber la farnésyl-protéine transférase et la farnésylation de la protéine Ras oncogène.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0897303JP2000508631 CA2249641AU1997025425