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1. (WO1997036593) INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1997/036593 International Application No.: PCT/US1997/005144
Publication Date: 09.10.1997 International Filing Date: 27.03.1997
Chapter 2 Demand Filed: 05.09.1997
IPC:
C07D 401/06 (2006.01) ,C07D 403/06 (2006.01)
Applicants: WEI, Dong, D.[CN/US]; US (UsOnly)
WILLIAMS, Theresa, M.[US/US]; US (UsOnly)
MERCK & CO., INC.[US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
Inventors: WEI, Dong, D.; US
WILLIAMS, Theresa, M.; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data:
60/014,59303.04.1996US
9613460.627.06.1996GB
Title (EN) INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
(FR) INHIBITEURS DE LA FARNESYLE-PROTEINE TRANSFERASE
Abstract:
(EN) The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
(FR) La présente invention concerne des composés inhibiteurs de la farnésyle-protéine transférase (FTase) et de la farnésylation de la protéine oncogène Ras. L'invention concerne également, non seulement des compositions chimiothérapiques contenant les composés de l'invention, mais aussi des procédés d'inhibition de la farnésyle-protéine transférase et de la farnésylation de la protéine oncogène Ras.
Designated States: AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KG, KR, KZ, LC, LK, LR, LT, LV, MD, MG, MK, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TR, TT, UA, US, UZ, VN, YU
African Regional Intellectual Property Organization (ARIPO) (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)