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Machine translation
1. (WO1997036005) OLIGONUCLEOTIDE TREATMENTS AND COMPOSITIONS FOR HUMAN MELANOMA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/036005    International Application No.:    PCT/US1997/004703
Publication Date: 02.10.1997 International Filing Date: 24.03.1997
Chapter 2 Demand Filed:    23.10.1997    
IPC:
A61K 38/00 (2006.01), C12N 15/11 (2006.01)
Applicants: LYNX THERAPEUTICS, INC. [US/US]; 3832 Bay Center Place, Hayward, CA 94545 (US) (For All Designated States Except US).
ZUPI, Gabriella [IT/IT]; (IT) (For US Only)
Inventors: ZUPI, Gabriella; (IT)
Agent: NAKAMURA, Jackie, N.; Cooley Godward L.L.P., 3000 El Camino Real, Five Palo Alto Square, Palo Alto, CA 94306-2155 (US).
BRADBURNE, James, A.; Cooley Godward L.L.P., 3000 El Camino Real, Five Palo Alto Square, Palo Alto, CA 94306-2155 (US)
Priority Data:
60/014,089 26.03.1996 US
Title (EN) OLIGONUCLEOTIDE TREATMENTS AND COMPOSITIONS FOR HUMAN MELANOMA
(FR) TRAITEMENTS A BASE D'OLIGONUCLEOTIDES ET COMPOSITIONS CONTRE LES MELANOMES HUMAINS
Abstract: front page image
(EN)The invention generally provides for compositions and methods of inhibiting the proliferation of human melanoma cancer cells. By administering a therapeutically effective amount of a $i(c-myc) oligonucleotide to a human melanoma cancer cell, melanoma cancer cell proliferation can be arrested or inhibited, metastases reduced from a tumor, and apoptosis induced in melanoma cancer cells. Oligonucleotides that are complementary to $i(c-myc) polynucleotides are referred to herein as '$i(c-myc) oligonucleotides'. A particularly efficacious embodiment of the invention relates to compositions and methods concerning the co-administration of $i(c-myc) oligonucleotides and cisplatin.
(FR)L'invention concerne des compositions et des procédés servant à inhiber la prolifération des cellules cancéreuses de mélanomes humains. L'administration d'une quantité efficace sur le plan thérapeutique d'un oligonucléotide de $i(c-myc) à une cellule cancéreuse de mélanome permet d'inhiber ou d'arrêter la prolifération cellulaire, de limiter les métastases à partir d'une tumeur et de provoquer l'apoptose dans les cellules cancéreuses du mélanome. Les oligonucléotides complémentaires des polynucléotides de $i(c-myc) sont désignés 'oligonucléotides de $i(c-myc)'. Un mode de réalisation particulièrement efficace de l'invention concerne des compositions et des procédés relatifs à l'administration conjointe d'oligonucléotides de $i(c-myc) et de cisplatine.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)