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1. WO1997035887 - PRECURSORS OF CATALYTIC ANTIBODIES

Publication Number WO/1997/035887
Publication Date 02.10.1997
International Application No. PCT/AU1997/000194
International Filing Date 26.03.1997
Chapter 2 Demand Filed 07.08.1997
IPC
C07K 14/475 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
475Growth factors; Growth regulators
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
42against immunoglobulins (anti-idiotypic antibodies)
C12N 9/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
CPC
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • AMRAD OPERATIONS PTY. LTD. [AU]/[AU] (AllExceptUS)
  • KOENTGEN, Frank [DE]/[AU] (UsOnly)
  • SUESS, Gabriele, Maria [DE]/[AU] (UsOnly)
  • TARLINTON, David, Mathew [AU]/[AU] (UsOnly)
  • TREUTLEIN, Herbert, Rudolf [DE]/[AU] (UsOnly)
Inventors
  • KOENTGEN, Frank
  • SUESS, Gabriele, Maria
  • TARLINTON, David, Mathew
  • TREUTLEIN, Herbert, Rudolf
Agents
  • HUGHES, E., John, L.
Priority Data
PN 895126.03.1996AU
PO 537527.02.1997AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRECURSORS OF CATALYTIC ANTIBODIES
(FR) PRECURSEURS D'ANTICORPS CATALYTIQUES
Abstract
(EN)
The invention is directed to growth factors or precursors of catalytic antibodies comprising a B-cell surface molecule binding portion, which can induce B-cell mitogenesis. The preferred B-cell surface molecule binding portions are the immunoglobulin binding molecules of protein L from peptostreptococcus magnus, protein A, protein G and protein H. The growth factor having an ability to induce B-cell mitogenesis can be further linked to a target antigen to which catalytic antibodies are sought. B-cell mitogenesis is then dependent on the catalytic cleavage of the antigen portion of the growth factor by catalytic antibodies on the surface of B cells. The method of the present invention is useful for generating catalytic antibodies for both therapeutic and diagnostic purposes.
(FR)
L'invention concerne des facteurs de croissance de précurseurs d'anticorps catalytiques comprenant une fraction de liaison de molécules à la surface de cellules B pouvant conduire à une mitogenèse des cellules B. Le fraction privilégiée de liaison de molécules à la surface des cellules B est constituée des molécules de liaison de l'immunoglobuline de la protéine L provenant de $i(Peptostreptococcus magnus), de la protéine A, de la protéine G et de la protéine H. Le facteur de croissance susceptible de conduire à une mitogenèse des cellules B peut également être lié à un antigène cible contre lequel on recherche des anticorps catalytiques. La mitogenèse des cellules B dépend alors de la segmentation catalytique de la fraction antigène du facteur de croissance par des anticorps catalytiques à la surface des cellules B. La technique relevant de la présente invention est utile pour produire des anticorps catalytiques à des fins thérapeutiques et diagnostiques.
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