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Machine translation
1. (WO1997035876) COMPOUNDS WHICH PREVENT NEURONAL CELL DEATH AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/035876    International Application No.:    PCT/US1997/004158
Publication Date: 02.10.1997 International Filing Date: 04.03.1997
Chapter 2 Demand Filed:    03.10.1997    
IPC:
A61K 38/00 (2006.01), C12N 9/64 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; West 116th Street and Broadway, New York, NY 10027 (US) (For All Designated States Except US).
TROY, Carol, M. [US/US]; (US) (For US Only)
Inventors: TROY, Carol, M.; (US)
Agent: WHITE, John, P.; Cooper & Dunham L.L.P., 1185 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
08/610,220 04.03.1996 US
Title (EN) COMPOUNDS WHICH PREVENT NEURONAL CELL DEATH AND USES THEREOF
(FR) COMPOSES EMPECHANT LA MORT CELLULAIRE NEURONALE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides for a compound having the structure: (AA¿1?)¿n?-Cys-(AA¿2?)¿m? wherein n = 0, 1, 2, 3, 4 or 5 and m = 0, 1, 2, 3, 4 or 5, provided the sum of (n + m) is greater than or equal to two and less than or equal to five, if n = 1, (AA¿1?)¿n? = Ala-, if n = 2, (AA¿1?)¿n? = Gln-Ala, if n $m(G) 3, (AA¿1?)¿n? = (Xaa)¿p?-Gln-Ala-, and Xaa = any amino acid and wherein if n = n3, p = 1, if n = 4, p = 2, if n = 5, p = 3, if m = 1, (AA¿2?)¿m? = -Arg, if m = 2, (AA¿2?)¿m? = -Arg-Gly, if m $m(G) 3, (AA¿2?)¿m? = -Arg-Gly-(Xaa)¿q?, wherein if m = 3, q = 1, if m = 4, q = 2, if m = 5, q = 3. The present invention provides for a method of inhibiting cell death and a method for alleviating symptoms of a neurodegenerative disorder in a subject.
(FR)La présente invention concerne un composé présentant la structure: (AA¿1?)¿n?-Cys-(AA¿2?)¿m? dans laquelle n = 0, 1, 2, 3, 4 ou 5 et m = 0, 1, 2, 3, 4 ou 5, à condition que la somme de (n + m) soit supérieure ou égale à deux et inférieure ou égale à cinq, si n = 1, (AA¿1?)¿n? = Ala-, si n = 2, (AA¿1?)¿n? = Gln-Ala, si n $m(G) 3, (AA¿1?)¿n? = (Xaa)¿p?-Gln-Ala-, et Xaa = n'importe quel acide aminé et dans laquelle si n = n3, p = 1, si n = 4, p = 2, si n = 5, p = 3, si m = 1, (AA¿2?)¿m? = -Arg, si m = 2,(AA¿2?)¿m? = -Arg-Gly, si m $m(G) 3, (AA¿2?)¿m? = -Arg-Gly-(Xaa)¿q?, dans laquelle si m = 3, q = 1, si m = 4, q = 2, si m = 5, q = 3. La présente invention concerne un procédé d'inhibition de la mort cellulaire et un procédé soulageant les symptômes de troubles neurodégénératifs chez un sujet.
Designated States: AU, CA, JP, MX, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)