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Machine translation
1. (WO1997035874) PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N-[1-[3-[(AMINOIMINOMETHYL)AMINO]PROPYL]-3,3-DIFLUORO-2-OXOHEXYL]-L-PROLINAMIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/035874    International Application No.:    PCT/US1997/002869
Publication Date: 02.10.1997 International Filing Date: 25.02.1997
Chapter 2 Demand Filed:    03.10.1997    
IPC:
C07C 277/08 (2006.01), C07K 5/06 (2006.01)
Applicants: HOECHST MARION ROUSSEL, INC. [US/US]; 2110 East Galbraith Road, P.O. Box 156300, Cincinnati, OH 45215-6300 (US)
Inventors: RUDISILL, Duane, E.; (US)
Agent: BOUDREAUX, William, R.; Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, P.O. Box 156300, Cincinnati, OH 45215-6300 (US)
Priority Data:
08/624,721 26.03.1996 US
Title (EN) PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N-[1-[3-[(AMINOIMINOMETHYL)AMINO]PROPYL]-3,3-DIFLUORO-2-OXOHEXYL]-L-PROLINAMIDE
(FR) PROCEDE DE PREPARATION DE N-METHYL-D-PHENYLALANYL-N-[1-[3-[(AMINOIMINOMETHYL)AMINO]PROPYL]-3,3-DIFLUORO-2-OXOHEXYL]-L-PROLINAMIDE
Abstract: front page image
(EN)The present invention relates to a novel process for preparing $i(N)-methyl-D-phenylalanyl-$i(N)-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-L-prolinamide or a pharmaceutically acceptable salt therof and to a key intermediate by directly guanylating Dakin-West intermediates.
(FR)Cette invention a trait à un nouveau procédé de préparation de $i(N)-méthyl-D-phénylalanyl-$i(N)-[1-[3-[(aminoiminométhyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-L-prolinamide ou d'un sel de cette substance, acceptable du point de vue pharmaceutique. Elle concerne également un intermédiaire décisif obtenu par la guanylation directe d'intermédiaires de Dakin-West.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN, YU.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)