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Machine translation
1. (WO1997035841) METHOD FOR OBTAINING PURE ENANTIOMERS OF A PYRIDAZINONE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/035841    International Application No.:    PCT/FI1997/000196
Publication Date: 02.10.1997 International Filing Date: 27.03.1997
Chapter 2 Demand Filed:    22.10.1997    
IPC:
C07D 237/04 (2006.01)
Applicants: ORION-YHTYMÄ OY [FI/FI]; Orionintie 1, FIN-02200 Espoo (FI) (For All Designated States Except US).
TIMMERBACKA, Mika [FI/FI]; (FI) (For US Only).
LEHTONEN, Jorma [FI/FI]; (FI) (For US Only).
TANNINEN, Veli, Pekka [FI/FI]; (FI) (For US Only).
MUTTONEN, Esa [FI/FI]; (FI) (For US Only).
KAUKONEN, Jukka [FI/FI]; (FI) (For US Only).
HYPPÖLÄ, Riikka [FI/FI]; (FI) (For US Only).
BÄCKSTRÖM, Reijo [FI/FI]; (FI) (For US Only)
Inventors: TIMMERBACKA, Mika; (FI).
LEHTONEN, Jorma; (FI).
TANNINEN, Veli, Pekka; (FI).
MUTTONEN, Esa; (FI).
KAUKONEN, Jukka; (FI).
HYPPÖLÄ, Riikka; (FI).
BÄCKSTRÖM, Reijo; (FI)
Agent: ORION CORPORATION; Orion Pharma, Patent Service, P.O. Box 65, FIN-02101 Espoo (FI)
Priority Data:
9606474.6 27.03.1996 GB
Title (EN) METHOD FOR OBTAINING PURE ENANTIOMERS OF A PYRIDAZINONE DERIVATIVE
(FR) PROCEDE D'OBTENTION D'ENANTIOMERES PURS D'UN DERIVE DE PYRIDAZINONE
Abstract: front page image
(EN)A method for preparing optically substantially pure (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone intermediate is described. The end product is useful as a cardiotonic agent. A novel crystalline polymorphic form of the end product is also described.
(FR)La présente invention concerne un procédé de préparation de (-)-[[4-(1,4,5,6-tétrahydro-4-méthyl-6-oxo-3-pyridazinyl)phényl]hydrazono]propanedinitrile à partir d'un intermédiaire, en l'occurrence un 6-(4-aminophényl)-4,5-dihydro-5-méthyl-3(2H)pyridazinone racémique. Le produit fini convient particulièrement comme tonicardiaque. L'invention concerne également une forme cristalline polymorphe nouvelle.
Designated States: AU, BA, BG, BR, CA, CN, CZ, EE, GE, HU, IL, IS, JP, KR, LT, LV, MK, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TR, UA, US, UZ.
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)