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1. (WO1997035621) SCLERAL PLUG CONTAINING PROTEINACEOUS MEDICINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/035621    International Application No.:    PCT/JP1997/000939
Publication Date: 02.10.1997 International Filing Date: 19.03.1997
Chapter 2 Demand Filed:    07.07.1997    
IPC:
A61K 9/00 (2006.01), A61K 9/51 (2006.01), A61K 38/21 (2006.01)
Applicants: SANTEN PHARMACEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Osaka-shi, Osaka 533 (JP) (For All Designated States Except US).
OGURA, Yuichiro [JP/JP]; (JP) (For US Only).
KUNOU, Noriyuki [JP/JP]; (JP) (For US Only).
OTA, Atsutoshi [JP/JP]; (JP) (For US Only)
Inventors: OGURA, Yuichiro; (JP).
KUNOU, Noriyuki; (JP).
OTA, Atsutoshi; (JP)
Agent: KISHIMOTO, Einosuke; Inaba Building, 3rd floor, 13-18, Nishishinsaibashi 1-chome, Chuo-ku, Osaka-shi, Osaka 542 (JP)
Priority Data:
8/68609 25.03.1996 JP
Title (EN) SCLERAL PLUG CONTAINING PROTEINACEOUS MEDICINE
(FR) OBTURATEUR SCLERAL CONTENANT DES MEDICAMENTS PROTEINIQUES
Abstract: front page image
(EN)A technique is provided which enables proteinaceous medicines, such as interferon-$g(b), to be effectively applied to diseases of intraocular portions, such as the vitreous body or retina. Specifically, a composition comprising a proteinaceous medicine adsorbed onto the surfaces of fine particles of a lactic acid copolymer; and a scleral plug prepared by molding this composition. The average particle diameter of the fine particle is less than 1000 nm, preferably 50 to 500 nm. The proteinaceous medicine is, for example, interferon, particularly interferon-$g(b). Preferably, the lactic acid copolymer comprises lactic acid units and glycolic acid units.
(FR)L'invention concerne une technique qui permet d'administrer efficacement des médicaments protéiniques, tels que l'interféron $g(b), pour traiter des maladies de parties intraoculaires, telles que le corps vitré ou la rétine. Plus particulièrement, l'invention concerne une composition contenant un médicament protéinique adsorbé sur les surfaces de particules fines d'un copolymère de l'acide lactique; et un obturateur scléral, réalisé par moulage à partir de cette composition. Le diamètre moyen des particules fines est inférieur à 1000 nm et, de préférence, il est de 50 à 500 nm. Le médicament protéinique est, par exemple, l'interféron, en particulier l'interféron $g(b). De préférence, le copolymère de l'acide lactique contient des unités acide lactique et des unités acide glycolique.
Designated States: CA, CN, KR, NO, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)