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Machine translation
1. (WO1997035538) TUMOR NECROSIS FACTOR ALPHA CONVERTASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/035538    International Application No.:    PCT/EP1997/001497
Publication Date: 02.10.1997 International Filing Date: 25.03.1997
Chapter 2 Demand Filed:    06.10.1997    
IPC:
C07C 323/60 (2006.01), C07D 513/04 (2006.01), C12N 9/64 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN (GB) (For All Designated States Except US).
McGEEHAN, Gerard, M. [US/US]; (US) (For US Only).
BECHERER, James, David [US/US]; (US) (For US Only).
MOSS, Marcia, L. [US/US]; (US) (For US Only).
SCHOENEN, Frank, J. [US/US]; (US) (For US Only).
ROCQUE, Warren, J. [US/US]; (US) (For US Only).
CHEN, Wen-Ji [US/US]; (US) (For US Only).
DIDSBURY, John, R. [US/US]; (US) (For US Only).
JIN, Shiow-Lian, Catherine [US/US]; (US) (For US Only)
Inventors: McGEEHAN, Gerard, M.; (US).
BECHERER, James, David; (US).
MOSS, Marcia, L.; (US).
SCHOENEN, Frank, J.; (US).
ROCQUE, Warren, J.; (US).
CHEN, Wen-Ji; (US).
DIDSBURY, John, R.; (US).
JIN, Shiow-Lian, Catherine; (US)
Agent: LANE, Graham, M., H.; Glaxo Wellcome plc, Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex UB6 0NN (GB)
Priority Data:
08/620,663 26.03.1996 US
Title (EN) TUMOR NECROSIS FACTOR ALPHA CONVERTASE
(FR) CONVERTASE DU FACTEUR ALPHA DE NECROSE TUMORALE
Abstract: front page image
(EN)The present invention relates to tumor necrosis factor alpha (TNF$g(a)), and more specifically to the enzyme TNF$g(a)-convertase (TNF$g(a)-con) that can proteolytically convert TNF$g(a) precursor to mature TNF$g(a). The present invention provides DNA sequences encoding mammalian TNF$g(a)-con and functional equivalents thereof, recombinant expression vectors comprising said DNA sequences, host cell lines comprising said expression vectors, inhibitors of TNF$g(a)-con, inhibitors modified for use as ligands for affinity purification of TNF$g(a)-con, and methods for treating diseases or conditions resulting from abnormal levels of TNF$g(a) in a mammalian subject.
(FR)L'invention porte sur le facteur alpha de nécrose tumorale (TNF$g(a)) et plus particulièrement sur l'enzyme TNF$g(a)-convertase (TNF$g(a)-con) assurant la conversion protéolytique du précurseur du TNF$g(a) en TNF$g(a) à maturité. L'invention porte sur des séquences d'ADN codant pour la TNF$g(a)-con de mammifère et ses équivalents fonctionnels, sur les vecteurs d'expression de recombinaison comprenant lesdites séquences d'ADN, sur des lignées de cellules hôtes comprenant lesdits vecteurs d'expression, sur des inhibiteurs de la TNF$g(a)-con, sur des inhibiteurs modifiés pour servir de ligands pour la purification de la TNF$g(a)-con par affinité, et sur des procédés de traitement de maladies ou d'états pathologiques dus à des taux anormaux de TNF$g(a) chez des mammifères.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN, YU.
African Regional Intellectual Property Organization (GH, KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)