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1. WO1997035537 - IMPROVEMENTS IN OR RELATING TO ENCAPSULATION

Publication Number WO/1997/035537
Publication Date 02.10.1997
International Application No. PCT/GB1997/000838
International Filing Date 25.03.1997
Chapter 2 Demand Filed 22.10.1997
IPC
A61J 3/07 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
07into the form of capsules or similar small containers for oral use
A61K 9/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
C08J 5/12 2006.01
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
5Manufacture of articles or shaped materials containing macromolecular substances
12Bonding of a preformed macromolecular material to the same or other solid material such as metal, glass, leather, e.g. using adhesives
CPC
A61J 3/07
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
07into the form of capsules or similar small containers for oral use
A61K 8/11
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
11Encapsulated compositions
A61K 8/8129
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
81obtained by reactions involving only carbon-to-carbon unsaturated bonds
8129Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
A61K 9/4816
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
4816Wall or shell material
A61Q 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
10Washing or bathing preparations
C08J 5/122
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
5Manufacture of articles or shaped materials containing macromolecular substances
12Bonding of a preformed macromolecular material to the same or other solid material such as metal, glass, leather, e.g. using adhesives
122using low molecular chemically inert solvents, swelling or softening agents
Applicants
  • BIOPROGRESS TECHNOLOGY LIMITED [GB]/[GB] (AllExceptUS)
  • BROWN, Malcolm, David [GB]/[GB] (UsOnly)
Inventors
  • BROWN, Malcolm, David
Agents
  • KEITH W. NASH & CO.
Priority Data
9606371.426.03.1996GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVEMENTS IN OR RELATING TO ENCAPSULATION
(FR) AMELIORATIONS EN MATIERE D'ENCAPSULATION
Abstract
(EN)
A method of encapsulation is characterised by supplying to an encapsulation unit (22) two films (14, 16) of like material capable of deforming elastically at least when partially solvated, and applying solvent to at least one of the films prior to encapsulation to cause partial solvation of the material surface, such that the partially solvated surface can adhere to and seal with the film material. In the encapsulation unit, the substance to be encapsulated e.g. a cosmetic oil or vitamin preparation is supplied between the films, the films are formed, typically by a moulding process, into suitably shaped capsule portions which can adhere to each other as a result of the adhesive action of the partially solvated surface(s), and which seal together encapsulating the supplied substance, forming a capsule. The invention enables encapsulation using materials other than gelatin, such as polyvinyl alcohol. Also disclosed is encapsulation apparatus and the resulting capsules.
(FR)
Technique d'encapsulation selon laquelle deux pellicules (14, 16) de matériaux semblables susceptibles de se déformer de façon élastique, du moins lorsqu'ils sont soumis à une solvatation partielle, sont amenés dans un élément d'encapsulation (22). Un solvant est appliqué sur l'une au moins des pellicules avant l'encapsulation pour produire une solvatation partielle de la surface du matériau, de façon que la surface soumise à la solvatation partielle puisse adhérer au matériau de la pellicule et s'unir à celui-ci. Dans l'élément d'encapsulation, la substance à encapsuler, par exemple une huile cosmétique ou une préparation à base de vitamines, passe entre les pellicules. On donne aux pellicules, généralement par moulage, la forme voulue de parties de gélules qui peuvent se coller l'une et l'autre en raison de l'adhérence de la ou des surfaces soumises à une solvatation partielle. Ces parties se collent ensemble en enfermant la substance fournie et forment une gélule. L'invention permet de procéder à une encapsulation en utilisant des matériaux autres que la gélatine, comme l'alcool de polyvinyle. L'invention décrit aussi un appareil d'encapsulation et les gélules résultantes.
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