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1. WO1997033891 - PROCESS FOR THE PREPARATION OF ß-LACTAM COMPOUNDS

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Publication Number WO/1997/033891
Publication Date 18.09.1997
International Application No. PCT/JP1997/000709
International Filing Date 07.03.1997
IPC
C07D 205/095 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
06having one double bond between ring members or between a ring member and a non-ring member
08with one oxygen atom directly attached in position 2, e.g. beta-lactams
09with a sulfur atom directly attached in position 4
095and with a nitrogen atom directly attached in position 3
C07D 501/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
CPC
C07D 205/095
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
06having one double bond between ring members or between a ring member and a non-ring member
08with one oxygen atom directly attached in position 2, e.g. beta-lactams
09with a sulfur atom directly attached in position 4
095and with a nitrogen atom directly attached in position 3
C07D 501/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
C07D 501/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
02Preparation
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of bulk chemicals
55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • OTSUKA KAGAKU KABUSHIKI KAISHA [JP]/[JP] (AllExceptUS)
  • TORII, Sigeru [JP]/[JP] (UsOnly)
  • TANAKA, Hideo [JP]/[JP] (UsOnly)
  • SASAOKA, Michio [JP]/[JP] (UsOnly)
  • KAMEYAMA, Yutaka [JP]/[JP] (UsOnly)
Inventors
  • TORII, Sigeru
  • TANAKA, Hideo
  • SASAOKA, Michio
  • KAMEYAMA, Yutaka
Agents
  • TAMURA, Iwao
Priority Data
8/8583313.03.1996JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF ß-LACTAM COMPOUNDS
(FR) PROCESSUS DE PREPARATION DE COMPOSES DE $g(b)-LACTAME
Abstract
(EN) A process for preparing allenyl-$g(b)-lactam compounds of general formula (II) or 3-halocephem compounds of general formula (III) from halogenated $g(b)-lactam compounds of general formula (I) under reaction conditions selected depending on the objective compound. In formula (I), R1 is hydrogen, amino or protected amino; R2 is optionally substituted aryl; n is 0 to 2; R3 is hydrogen or a carboxyl-protecting group; X is halogeno; and Y is halogeno or a leaving group. In formula (II), R1, R2, n and R3 are each as defined above. In formula (III), R1, R3 and X are each as defined above.
(FR) Cette invention concerne un processus de préparation de composés d'allényl-$g(b)-lactame ou de composés de 3-halocéphem à partir de composés de $g(b)-lactame halogénés correspondant à la formule générale (I) où R1 représente hydrogène, amino ou amino protégé, R2 représente un aryle éventuellement substitué, n varie entre 0 et 2, R3 représente hydrogène ou un groupe de protection de carboxyle, X représente halogéno et Y représente halogéno ou un groupe partant. Les conditions de réaction sont choisies en fonction du composé voulu, et permettent d'obtenir des composés d'allényl-$g(b)-lactame correspondant à la formule générale (II) où R1, R2, n et R3 sont tels que définis précédemment, ainsi que des composés de 3-halocéphem correspondant à la formule générale (III) où R1, R3 et X sont tels que définis précédemment.
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