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1. WO1997033606 - PROGRAMMED CELL DEATH AND INTERLEUKIN-1$g(b)

Publication Number WO/1997/033606
Publication Date 18.09.1997
International Application No. PCT/US1996/003468
International Filing Date 15.03.1996
Chapter 2 Demand Filed 06.10.1997
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
C07K 16/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
CPC
A61K 38/191
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
A61K 38/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
A61K 38/2006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
2006IL-1
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 16/244
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
244Interleukins [IL]
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US]/[US]
Inventors
  • YUAN, Junying
  • FRIEDLANDER, Robert
Agents
  • GOLDSTEIN, Jorge, A.
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROGRAMMED CELL DEATH AND INTERLEUKIN-1$g(b)
(FR) MORT CELLULAIRE PROGRAMMEE ET INTERLEUKINE-1$g(b)
Abstract
(EN) Methods for modulating programmed cell death are provided. Apoptosis, induced by a variety of stimuli, can be inhibited by blocking IL-1$g(b) binding to its type-1 receptor. Additionally, IL-1$g(b) had anti-apoptotic activity when added exogenously prior to exposure to apoptotic stimuli. ICE cleavage of pro-IL-1$g(b) is an important step in apoptosis, and mature IL-1$g(b) may function as a positive or negative mediator of cell death.
(FR) Cette invention concerne des procédés permettant de moduler la mort cellulaire programmée. L'apoptose, qui est induite par divers stimuli, peut être inhibée en empêchant l'IL-1$g(b) de se lier son récepteur de type 1. L'IL-1$g(b) possède en outre une activité anti-apoptique lorsqu'elle est ajoutée de manière exogène avant l'exposition aux stimuli apoptiques. Le clivage par enzyme de conversion (ICE) de pro-IL-1$g(b) représente une étape importante dans l'apoptose, l'IL-1$g(b) mûrie pouvant avoir la fonction de médiateur positif ou négatif dans la mort cellulaire.
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