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1. WO1997031931 - A NOVEL DISINTEGRIN METALLOPROTEASE AND METHODS OF USE

Publication Number WO/1997/031931
Publication Date 04.09.1997
International Application No. PCT/US1997/003217
International Filing Date 28.02.1997
Chapter 2 Demand Filed 29.09.1997
IPC
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12N 9/64 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
48acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50Proteinases
64derived from animal tissue, e.g. rennin
G01N 33/573 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
573for enzymes or isoenzymes
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 49/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
C07H 21/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04with deoxyribosyl as saccharide radical
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
C12N 15/63
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Applicants
  • THE PROCTER & GAMBLE COMPANY [US]/[US] (AllExceptUS)
  • CASE WESTERN RESERVE UNIVERSITY [US]/[US] (AllExceptUS)
  • TINDAL, Michael, Howard [US]/[US] (UsOnly)
  • HAQQI, Tariq [IN]/[US] (UsOnly)
Inventors
  • TINDAL, Michael, Howard
  • HAQQI, Tariq
Agents
  • REED, T., David
Priority Data
60/012,67901.03.1996US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) A NOVEL DISINTEGRIN METALLOPROTEASE AND METHODS OF USE
(FR) NOUVELLE DISINTEGRINE-METALLOPROTEASE ET PROCEDES D'UTILISATION
Abstract
(EN) This invention provides a method for identifying compounds capable of binding to the disintegrin protein, and determining the amount and affinity of a compound capable of binding to the disintegrin protein in a sample. This invention also provides a host cell comprising a recombinant expression vector to the disintegrin protein and a recombinant expression vector encoding to the disintegrin protein and the human disintegrin metalloprotease protein, fragment or mutant thereof, useful for these purposes. This invention also provides an $i(in vivo) or $i(in vitro) method for screening for osteoarthritis and other metalloprotease based diseases, capable of manufacture and use in a kit form.
(FR) Cette invention se rapporte à un procédé pour identifier des composés capables de se lier à la protéine de disintégrine et pour déterminer la quantité et l'affinité d'un composé capable de se lier à la protéine de disintégrine dans un échantillon. Cette invention se rapporte également à une cellule hôte comprenant un vecteur d'expression recombiné pour la protéine de disintégrine et à un vecteur d'expression recombiné codant pour la protéine de disintégrine et pour la protéine de disintégrine-métalloprotéase humaine, un fragment ou un mutant de celle-ci utiles à ces fins. Cette invention se rapporte en outre à un procédé $i(in vivo) ou $i(in vitro) pour dépister l'ostéoarthrite et d'autres maladies associées à la métalloprotéase, procédé qui peut être réalisé et utilisé sous la forme de kit.
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