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1. WO1997031104 - CANDIDA ALBICANS PROFILIN GENE

Publication Number WO/1997/031104
Publication Date 28.08.1997
International Application No. PCT/US1997/003798
International Filing Date 20.02.1997
Chapter 2 Demand Filed 16.09.1997
IPC
C07K 14/40 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37from fungi
39from yeasts
40from Candida
C12Q 1/18 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
18Testing for antimicrobial activity of a material
CPC
C07K 14/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
37from fungi
39from yeasts
40from Candida
C12Q 1/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
18Testing for antimicrobial activity of a material
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US]
Inventors
  • GORMAN, Jessica, A.
  • OSTRANDER, Darin, B.
Agents
  • GAUL, Timothy, J.
Priority Data
60/012,07622.02.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CANDIDA ALBICANS PROFILIN GENE
(FR) GENE DE PROFILINE DE CANDIDA ALBICANS
Abstract
(EN)
An isolated nucleic acid molecule encoding $i(C. albicans) profilin. Preferably, the $i(C. albicans) profilin has the amino acid sequence of SEQ. ID. NO.: 2 and the nucleotide sequence of SEQ. ID. NO.: 1. The invention also concerns a nucleic acid molecule having a sequence complementary to the above sequences of 5' and 3' flanking regions thereof. The invention further concerns nucleic acid vectors comprising a DNA sequence coding for $i(C. albicans) profilin, host cells containing such vectors, and polypeptides comprising $i(C. albicans) profilin. Preferably, the polypeptide is full-length $i(C. albicans) profilin or recombinantly produced $i(C. albicans) profilin. The present invention also concerns methods for detecting nucleic acids coding for $i(C. albicans) profilin and for detecting anti-fungal agents that target $i(C. albicans) profilin.
(FR)
L'invention concerne une molécule isolée d'acide nucléique codant pour la profiline de $i(C. albicans). De préférence, la profiline de $i(C. albicans) a pour séquence d'aminoacides SEQ. ID. NO.: 2 et pour séquence de nucléotides SEQ. ID. NO.:1. L'invention concerne, également, une molécule d'acide nucléique ayant la séquence complémentaire des séquences ci-dessus et des séquences latérales de celles-ci, sur le côté 3' ou 5'. L'invention concerne, en outre, des vecteurs d'acide nucléique comprenant une séquence d'ADN codant pour la profiline de $i(C. albicans), des cellules hôtes contenant de tels vecteurs et des polypeptides contenant la profiline de $i(C. albicans). De préférence, le polypeptide est une profiline complète de $i(C. albicans) ou une profiline de $i(C. albicans) de recombinaison. L'invention concerne, également, des procédés pour détecter les acides nucléiques codant pour la profiline de $i(C. albicans) et pour identifier des agents antifongiques agissant contre la profiline de $i(C. albicans).
Also published as
Latest bibliographic data on file with the International Bureau