Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997030040 - NOVEL TETRAHYDRONAPHTHOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME

Publication Number WO/1997/030040
Publication Date 21.08.1997
International Application No. PCT/JP1997/000451
International Filing Date 19.02.1997
Chapter 2 Demand Filed 27.06.1997
IPC
C07D 307/92 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
92Naphthofurans; Hydrogenated naphthofurans
C07D 407/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 407/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
14containing three or more hetero rings
C07D 409/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 307/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
77ortho- or peri-condensed with carbocyclic rings or ring systems
92Naphthofurans; Hydrogenated naphthofurans
C07D 407/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 407/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
14containing three or more hetero rings
C07D 409/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • MEIJI SEIKA KABUSHIKI KAISHA [JP]/[JP] (AllExceptUS)
  • KURIHARA, Kenichi [JP]/[JP] (UsOnly)
  • SHINEI, Rie [JP]/[JP] (UsOnly)
  • TANABE, Kiyoshi [JP]/[JP] (UsOnly)
  • YAMAMOTO, Yasuo [JP]/[JP] (UsOnly)
  • AJITO, Keiichi [JP]/[JP] (UsOnly)
  • MIYAJIMA, Kaori [JP]/[JP] (UsOnly)
  • TABATA, Yuji [JP]/[JP] (UsOnly)
  • YASUDA, Shohei [JP]/[JP] (UsOnly)
  • TATSUTA, Kuniaki [JP]/[JP] (UsOnly)
  • OKONOGI, Tsuneo [JP]/[JP] (UsOnly)
Inventors
  • KURIHARA, Kenichi
  • SHINEI, Rie
  • TANABE, Kiyoshi
  • YAMAMOTO, Yasuo
  • AJITO, Keiichi
  • MIYAJIMA, Kaori
  • TABATA, Yuji
  • YASUDA, Shohei
  • TATSUTA, Kuniaki
  • OKONOGI, Tsuneo
Agents
  • SATO, Kazuo
Priority Data
8/22800529.08.1996JP
8/3106119.02.1996JP
8/33830818.12.1996JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL TETRAHYDRONAPHTHOFURANONE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
(FR) NOUVEAUX DERIVES DE TETRAHYDRONAPHTHOFURANONE ET PROCEDE DE PREPARATION CORRESPONDANT
Abstract
(EN)
Compounds represented by general formula (I) and pharmaceutically acceptable salts thereof, which have progesterone receptor binding inhibitory activities and so are used as remedies and preventives for diseases in which progesterone participates, more particularly, as anticancer agents against mammary and ovarian cancers, remedies for uterine myoma, endometriosis, meningioma and myeloma, abortifacient, peroral contraceptive, and remedies and preventives for osteoporosis and climacteric disturbance, wherein R1 and R2 represent each hydroxy, alkyloxy, alkenyloxy, alkynyloxy, cycloalkyloxy, alkoxyalkyloxy, oxygenous cycloalkyloxy, aralkyloxy, alkylcarbonyloxy, alkenylcarbonyloxy, alkynylcarbonyloxy, cycloalkylcarbonyloxy, alkoxycarbonyloxy, aryloxycarbonyloxy, aralkylcarbonyloxy, aromatic acyloxy, heteroaromatic acyloxy, saturated heterocyclic carbonyloxy, alkylsulfonyloxy, aromatic sulfonyloxy, alkylcarbamoyloxy, or aromatic carbamoyloxy, the R1 optionally representing hydrogen alkyl, alkenyl, or alkynyl; and R3, R4, and R5 represent each independently hydrogen, alkyl, or alkenyl.
(FR)
Cette invention concerne des composés représentés par la formule générale (I), ainsi que des sels pharmaceutiquement acceptables de ces composés, qui ont une activité inhibitrice de la liaison au récepteur de la progestérone et sont de ce fait utilisés en tant que remèdes et agents de prévention de maladies dans lesquelles la progestérone entre en jeu, et plus particulièrement en tant qu'agents anticancéreux utilisables dans le traitement des cancers du sein et des ovaires, et en tant que médicaments destinés au traitement du myome utérin, de l'endométriose, du méningiome et du myélome, en tant qu'agent abortif, que contraceptif peroral et en tant que remèdes et agents préventifs de l'ostéoporose et des troubles climatériques. Dans la formule (I), R1 et R2 sont chacun hydroxy, alkyloxy, alcényloxy, alcynyloxy, cycloalkyloxy, alcoxyalkyloxy, cycloalkyloxy d'oxygène, aralkyloxy, alkylcarbonyloxy, alcénylcarbonyloxy, alcynylcarbonyloxy, cycloalkylcarbonyloxy, alcoxycarbonyloxy, aryloxycarbonyloxy, aralkylcarbonyloxy, acyloxy aromatique, acyloxy hétéroaromatique, carbonyloxy hétérocyclique saturé, alkylsulfonyloxy, sulfonyloxy aromatique, alkylcarbamoyloxy, ou carbamoyloxy aromatique, R1 étant éventuellement alkyle d'hydrogène, alcényle, ou alcynyle, et R3, R4 et R5 sont chacun indépendamment hydrogène, alkyle ou alcényle.
Latest bibliographic data on file with the International Bureau