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1. WO1997029087 - CONTINUOUS PROCESSES FOR THE HYDROLYSIS OF CYANOPYRIDINES UNDER SUBSTANTIALLY ADIABATIC CONDITIONS

Publication Number WO/1997/029087
Publication Date 14.08.1997
International Application No. PCT/US1997/001657
International Filing Date 04.02.1997
Chapter 2 Demand Filed 04.09.1997
IPC
C07D 213/803 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
79Acids; Esters
803Processes of preparation
C07D 213/81 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81Amides; Imides
CPC
C07D 213/803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
79Acids; Esters
803Processes of preparation
C07D 213/81
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with heteroatoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78Carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals
81Amides; Imides
Applicants
  • REILLY INDUSTRIES, INC. [US]/[US] (AllExceptUS)
  • CAO, Wei [CN]/[US] (UsOnly)
  • KATTAU, Robert, A. [US]/[US] (UsOnly)
  • KREILIS, George [US]/[US] (UsOnly)
Inventors
  • CAO, Wei
  • KATTAU, Robert, A.
  • KREILIS, George
Agents
  • GANDY, Kenneth, A.
Priority Data
60/011,42409.02.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CONTINUOUS PROCESSES FOR THE HYDROLYSIS OF CYANOPYRIDINES UNDER SUBSTANTIALLY ADIABATIC CONDITIONS
(FR) PROCESSUS CONTINUS POUR L'HYDROLYSE DE CYANOPYRIDINES SOUS CONDITIONS SENSIBLEMENT ADIABATIQUES
Abstract
(EN)
Described are preferred processes for hydrolyzing substituted and unsubstituted cyanopyridines in the presence of a base and under substantially adiabatic conditions to produce pyridine substituted amides and/or pyridine substituted carboxylic acids. Preferred processes can be conducted in a variety of continuous reactors including cascades of reaction vessels, loop reactors or flow tube reactors. More preferred are the efficient and advantageous preparations of nicotinamide and niacin, which serve as important members of the B-vitamin complex.
(FR)
L'invention concerne des processus à préférer pour l'hydrolyse de cyanopyridine substituée et non substituée en présence d'une base, et sous conditions sensiblement adiabatiques, en vue de fabriquer des amides à substitution pyridine et/ou des acides carboxyliques à substitution pyridine. Il est possible de conduire les processus en question dans une variété de réacteurs continus, y compris les séries en cascades de cuves à réaction, réacteurs en boucles ou réacteurs à tube d'écoulement. On préfère en outre utiliser des préparations efficaces et avantageuses de nicotinamide et de niacine, qui représentent des constituants importants du complexe vitaminique B.
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