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1. WO1997029075 - SUBSTITUTED AMIDE DERIVATIVES

Publication Number WO/1997/029075
Publication Date 14.08.1997
International Application No. PCT/JP1997/000306
International Filing Date 07.02.1997
Chapter 2 Demand Filed 29.08.1997
IPC
C07C 233/01 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 235/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
CPC
C07C 233/01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
01having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 235/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
Applicants
  • BANYU PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • IWASAWA, Yoshikazu [JP]/[JP] (UsOnly)
  • AOYAMA, Tetsuya [JP]/[JP] (UsOnly)
  • KAWAKAMI, Kumiko [JP]/[JP] (UsOnly)
  • ARAI, Sachie [JP]/[JP] (UsOnly)
  • SATOH, Toshihiko [JP]/[JP] (UsOnly)
  • MONDEN, Yoshiaki [JP]/[JP] (UsOnly)
Inventors
  • IWASAWA, Yoshikazu
  • AOYAMA, Tetsuya
  • KAWAKAMI, Kumiko
  • ARAI, Sachie
  • SATOH, Toshihiko
  • MONDEN, Yoshiaki
Priority Data
8/4550407.02.1996JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) SUBSTITUTED AMIDE DERIVATIVES
(FR) DERIVES D'AMIDES SUBSTITUES
Abstract
(EN)
Compounds represented by general formula (I), pharmacologically acceptable salts or esters thereof, and antitumor agents comprising these as the active ingredients, wherein Ar1, Ar2, and Ar3 each represents aryl or heteroaryl; A1 represents C2-6 hydrocarbyl or a group represented by -A1a-W1-A1b- (where W1 represents oxygen, sulfur, ethynylene, cyclopropylene, or a group represented by -NRw-); A2 represents C2-8 hydrocarbyl; Q represents a group represented by -(CH2)m- or -(CH2)n-W2-(CH2)p- (where W2 represents oxygen, sulfur, vinylene, ethynylene, or a group represented by -NHCOCH=CH-); R1 represents hydrogen, halogeno, hydroxy, lower alkyl, lower alkoxy, aryl, or heteroaryl group; R2, R6, and R7 each represents hydrogen, halogeno, hydroxy, lower alkyl, lower alkenyl, or lower alkoxy; R3 and R4 each represents hydrogen, halogeno, hydroxy, amino, nitro, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkyl, lower hydroxyalkyl, lower fluoroalkyl, or lower alkoxy; and R5 represents lower alkyl.
(FR)
La présente invention concerne des composés représentés par la formule générale (I), certains de leurs sels ou esters galéniques et des agents antitumoraux les utilisant comme principes actifs. Dans cette formule générale, Ar1, Ar2 et Ar3 sont chacun aryle ou hétéroaryle. A1 est hydrocarbyle en C2-6 ou un groupe représenté par -A1a-W1-A1b- (W1 représentant un oxygène, soufre, éthynylène, cyclopropylène ou un groupe représenté par -NRw-). A2 est un groupe hydrocarbyle en C2-8. Q est un groupe représenté par -(CH2)m- ou -(CH2)n-W2-(CH2)p- (W2 étant oxygène, soufre, vinylène, éthynylène ou un groupe représenté par -NHCOCH=CH-). R1 est hydrogène, halogéno, hydroxy, alkyle inférieur, alcoxy inférieur, aryle ou un groupe hétéroaryle. R2, R6 et R7 sont chacun hydrogène, halogéno, hydroxy, alkyle inférieur, alcényle inférieur ou un alcoxy inférieur. R3 et R4 sont chacun hydrogène, halogéno, hydroxy, amino, nitro, cyano, carboxy, alcoxycarbonyle inférieur, carbamyle, alkylcarbamyle, alkyle inférieur, hydroxyalkyle inférieur, fluoroalkyle inférieur ou alcoxy inférieur. R5 est alkyle inférieur.
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