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1. WO1997028191 - MHC COMPLEXES AND USES THEREOF

Publication Number WO/1997/028191
Publication Date 07.08.1997
International Application No. PCT/US1997/001617
International Filing Date 30.01.1997
Chapter 2 Demand Filed 13.08.1997
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/74 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
74Major histocompatibility complex (MHC)
CPC
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/6043
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
6031Proteins
6043Heat shock proteins
A61K 2039/622
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
62characterised by the link between antigen and carrier
622non-covalent binding
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
Applicants
  • SUNOL MOLECULAR CORPORATION [US]/[US] (AllExceptUS)
  • RHODE, Peter, R. [US]/[US] (UsOnly)
  • JIAO, Jin-An [CN]/[US] (UsOnly)
  • BURKHARDT, Martin [US]/[US] (UsOnly)
  • WONG, Hing, C. [US]/[US] (UsOnly)
Inventors
  • RHODE, Peter, R.
  • JIAO, Jin-An
  • BURKHARDT, Martin
  • WONG, Hing, C.
Agents
  • HUANG, Bee
Priority Data
08/596,38731.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MHC COMPLEXES AND USES THEREOF
(FR) COMPLEXES MAJEURS D'HISTOCOMPATIBILITE ET LEUR UTILISATION
Abstract
(EN)
The present invention relates to novel complexes of major histocompatibility complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.
(FR)
Nouveaux complexes de molécules de complexe majeur d'histocompatibilité (CMH) et leurs utilisations. Selon l'un de ces aspects, l'invention porte sur des complexes majeurs d'histocompatibilité (CMH) chargés comprenant au moins une molécule CMH présentant une rainure de liaison peptidique, et un peptide donneur à liaison non covalente avec la protéine CMH. Selon un autre aspect, l'invention se caractérise par des complexes de fusion peptidique de classe II de CMH à chaîne unique dotés d'un peptide donneur lié de manière covalente à la rainure de liaison peptidique du complexe. Les complexes CMH de cette invention se révèlent utiles pour toute une série d'application, notamment: 1) les dépistages in vitro d'identification et d'isolement de peptides modulant l'activité de lymphocytes T choisis, y compris des peptides qui sont des antagonistes et des agonistes partiaux du récepteur des lymphocytes T, et 2) des méthodes de neutralisation ou d'induction d'une réponse immune chez un mammifère.
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