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1. WO1997027840 - SUSTAINED DELIVERY OF AN ACTIVE AGENT USING AN IMPLANTABLE SYSTEM

Publication Number WO/1997/027840
Publication Date 07.08.1997
International Application No. PCT/US1997/000722
International Filing Date 15.01.1997
Chapter 2 Demand Filed 18.08.1997
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 38/09 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
09Luteinising hormone-releasing hormone ; Related peptides
A61M 5/145 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
145using pressurised reservoirs, e.g. by means of pistons
CPC
A61K 38/09
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
09Luteinising hormone-releasing hormone [LHRH] ; , i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
A61K 9/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
A61K 9/0024
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
A61M 2005/14513
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
145using pressurised reservoirs, e.g. pressurised by means of pistons
14513with secondary fluid driving or regulating the infusion
A61M 2206/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2206Characteristics of a physical parameter; associated device therefor
10Flow characteristics
A61M 5/14526
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
142Pressure infusion, e.g. using pumps
145using pressurised reservoirs, e.g. pressurised by means of pistons
1452pressurised by means of pistons
14526the piston being actuated by fluid pressure
Applicants
  • ALZA CORPORATION [US]/[US] (AllExceptUS)
  • ECKENHOFF, Bonnie, J. [US]/[US] (UsOnly)
  • PEERY, John, R. [US]/[US] (UsOnly)
  • DIONNE, Keith, E. [US]/[US] (UsOnly)
  • LANDRAU, Felix, A. [US]/[US] (UsOnly)
  • LAUTENBACH, Scott, D. [US]/[US] (UsOnly)
  • MAGRUDER, Judy, A. [US]/[US] (UsOnly)
  • WRIGHT, Jeremy, C. [US]/[US] (UsOnly)
Inventors
  • PEERY, John, R.
  • DIONNE, Keith, E.
  • LANDRAU, Felix, A.
  • LAUTENBACH, Scott, D.
  • MAGRUDER, Judy, A.
  • WRIGHT, Jeremy, C.
  • ECKENHOFF, James, B.
Agents
  • DILLAHUNTY, Mary, Ann
Priority Data
08/595,76102.02.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUSTAINED DELIVERY OF AN ACTIVE AGENT USING AN IMPLANTABLE SYSTEM
(FR) ADMINISTRATION PROLONGEE D'UN AGENT ACTIF A L'AIDE D'UN SYSTEME IMPLANTABLE
Abstract
(EN)
The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.
(FR)
L'invention concerne un dispositif d'administration d'une formulation d'agent actif pendant une durée d'administration prédéterminée. Un réservoir imperméable est divisé en une chambre d'agent gonflant au contact de l'eau et une chambre de formulation d'agent actif. Le fluide provenant du milieu permet une imbibition à travers un bouchon semi-perméable à l'intérieur de la chambre d'agent gonflant au contact de l'eau et la formulation d'agent actif est libérée par une sortie régulatrice à diffusion en retour. On peut atteindre des durées d'administration allant jusqu'à 2 ans.
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