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1. WO1997027752 - INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

Publication Number WO/1997/027752
Publication Date 07.08.1997
International Application No. PCT/US1997/001599
International Filing Date 27.01.1997
Chapter 2 Demand Filed 22.08.1997
IPC
A61K 31/4164 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
CPC
A61K 31/4164
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
Applicants
  • MERCK & CO., INC. [US]/[US] (AllExceptUS)
  • DINSMORE, Christopher, J. [US]/[US] (UsOnly)
  • HARTMAN, George, D. [US]/[US] (UsOnly)
Inventors
  • DINSMORE, Christopher, J.
  • HARTMAN, George, D.
Common Representative
  • MERCK & CO., INC.
Priority Data
60/010,86030.01.1996US
9605699.919.03.1996GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
(FR) INHIBITEURS DE LA FARNESYL-PROTEINE TRANSFERASE
Abstract
(EN)
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
(FR)
Composés inhibants la farnésyl-protéine transférase (FTase) et la farnésylation du Ras protéique oncogène. L'invention porte en outre sur des compositions chimiothérapeutiques renfermant les composés de cette invention et sur des méthodes d'inhibitions de la farnésyl-protéine transférase et de la farnésylation du Ras protéique oncogène.
Also published as
Latest bibliographic data on file with the International Bureau