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1. WO1997027486 - REAGENTS FOR USE AS CALIBRATORS AND CONTROLS

Publication Number WO/1997/027486
Publication Date 31.07.1997
International Application No. PCT/US1997/001074
International Filing Date 17.01.1997
Chapter 2 Demand Filed 25.08.1997
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/96 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
96involving blood or serum control standard
CPC
G01N 33/6854
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6854Immunoglobulins
G01N 33/6857
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6854Immunoglobulins
6857Antibody fragments
G01N 33/96
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
96involving blood or serum control standard
Applicants
  • ABBOTT LABORATORIES [US]/[US]
Inventors
  • HACKETT, John, R., Jr.
  • HOFF, Jane, A.
  • OSTROW, David, H.
  • GOLDEN, Alan, M.
Agents
  • BECKER, Cheryl, L.
Priority Data
08/589,93923.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REAGENTS FOR USE AS CALIBRATORS AND CONTROLS
(FR) REACTIFS S'UTILISANT COMME ETALONS ET TEMOINS
Abstract
(EN)
The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.
(FR)
L'invention concerne l'utilisation d'un réactif se fixant de façon spécifique à un ligand prédéterminé, contenant un ou plusieurs déterminants antigéniques d'anticorps à régions constantes et présentant une spécificité, ainsi qu'une affinité, uniformes. On peut produire ce réactif en continu dans la fabrication d'étalons et/ou de témoins pour des trousses de diagnostics conçues pour mesurer qualitativement ou quantitativement des anticorps spécifiques pour un ligand souhaité. L'invention concerne, par exemple, des anticorps chimères recombinés de l'homme et de la souris, qu'on peut utiliser en tant qu'étalons et/ou de témoins positifs dans des techniques de dosage et dans des trousses mesurant les anticorps de l'homme. On peut utiliser toute espèce pour créer les anticorps chimères et on peut détecter la présence de toute espèce correspondante d'anticorps.
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