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1. WO1997027321 - MARKER AT THE ESTROGEN RECEPTOR GENE FOR DETERMINATION OF OSTEOPOROSIS PREDISPOSITION

Publication Number WO/1997/027321
Publication Date 31.07.1997
International Application No. PCT/CA1997/000047
International Filing Date 23.01.1997
Chapter 2 Demand Filed 19.08.1997
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • UNIVERSITE LAVAL [CA]/[CA]
Inventors
  • ROUSSEAU, François
Agents
  • COTE, France
Priority Data
08/592,83525.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MARKER AT THE ESTROGEN RECEPTOR GENE FOR DETERMINATION OF OSTEOPOROSIS PREDISPOSITION
(FR) MARQUEUR DU GENE RECEPTEUR DES OESTROGENES POUR LA DETERMINATION DES PREDISPOSITIONS A L'OSTEOPOROSE
Abstract
(EN)
The present invention relates to a method of determining predisposition to low or high bone mineral density and to development of osteoporosis of a patient, which comprises determining estrogen receptor polymorphism in linkage disequilibrium in a biological sample of said patient, wherein heterozygosity is associated with high bone density and homozygosity is associated with low bone density.
(FR)
L'invention concerne un procédé de détermination des prédispositions à une densité osseuse à forte ou faible teneur en substances minérales et à l'apparition de l'ostéoporose chez un patient, ce procédé consistant à évaluer le polymorphisme des récepteurs d'oestrogènes dans le déséquilibre de liaison d'un échantillon biologique prélevé chez le patient, l'hétérozygotie étant associée à une forte teneur de l'os en substances minérales et l'homozygotie étant associée à une faible teneur de l'os en substances minérales.
Also published as
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