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1. WO1997027311 - MIXTURE OF RECOMBINANT VACCINIA VECTORS AS POLYENV VACCINES FOR HIV

Publication Number WO/1997/027311
Publication Date 31.07.1997
International Application No. PCT/US1997/000669
International Filing Date 23.01.1997
Chapter 2 Demand Filed 22.08.1997
IPC
A61K 38/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
C07K 14/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16HIV-1
C12N 15/863 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
863Poxviral vectors, e.g. vaccinia virus
CPC
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
Applicants
  • ST. JUDE CHILDREN'S RESEARCH HOSPITAL [US]/[US]
Inventors
  • HURWITZ, Julia
  • COLECLOUGH, Christopher
  • OWENS, Randall
  • SLOBOD, Karen
Agents
  • FEHLNER, Paul, F.
  • DAVIS, Michael, D.
Priority Data
08/590,28823.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MIXTURE OF RECOMBINANT VACCINIA VECTORS AS POLYENV VACCINES FOR HIV
(FR) MELANGE DE VECTEURS DE RECOMBINAISON DU VIRUS DE LA VACCINE UTILISES COMME VACCINS POLYENV CONTRE LE VIH
Abstract
(EN)
Polyenv vaccines are provided that comprise mixtures of at least 4 to about 10.000 different recombinant viruses that each express a different HIV $i(env) variant or a portion thereof containing both constant and variable regions, as well as methods of making and using such polyenv vaccines and viruses, including the use of the polyenv vaccine, in live, attenuated or inactivated form, for prophylaxis or treatment of HIV infection. The viral vaccines of the invention are optimally combined with a recombinant HIV $i(env) booster, or a recombinant HIV $i(env) gene DNA priming or boosting vaccine.
(FR)
L'invention concerne des vaccins polyenv comprenant des mélanges d'au moins 4 à environ 10000 virus de recombinaison différents qui expriment chacun un variant $i(env) différent du VIH ou une partie de ce variant contenant des régions à la fois constantes et variables. L'invention concerne également des procédés de fabrication et d'utilisation de ces vaccins polyenv et virus, ainsi que l'utilisation du vaccin polyenv, sous forme vivante, atténuée ou inactivée, dans la prophylaxie ou le traitement des infections à VIH. Les vaccins viraux de l'invention sont combinés de manière optimale à un agent renforçateur $i(env) du VIH de recombinaison ou à un premier vaccin ou un rappel à ADN renfermant le gène $i(env) du VIH de recombinaison.
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