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1. WO1997027288 - NEW ATTENUATED STRAIN OF THE VIRUS CAUSING THE PORCINE REPRODUCTIVE RESPIRATORY SYNDROME (PRRS), VACCINES AND DIAGNOSTIC MEANS OBTAINABLE WITH SAID STRAIN, AND PRODUCTION PROCESS

Publication Number WO/1997/027288
Publication Date 31.07.1997
International Application No. PCT/ES1996/000234
International Filing Date 04.12.1996
IPC
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C12N 7/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61K 2039/5254
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5254avirulent or attenuated
A61K 2039/552
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
55characterised by the host/recipient, e.g. newborn with maternal antibodies
552Veterinary vaccine
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C12N 2770/10021
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
10011Arteriviridae
10021Viruses as such, e.g. new isolates, mutants or their genomic sequences
Applicants
  • LABORATORIOS HIPRA, S.A. [ES]/[ES] (AllExceptUS)
  • ALEMANY BURCH, Reina [ES]/[ES] (UsOnly)
  • ESPUÑA MASO, Enric [ES]/[ES] (UsOnly)
  • RIERA PUJADAS, Pere [ES]/[ES] (UsOnly)
  • SAUBI ROCA, Narcis [ES]/[ES] (UsOnly)
Inventors
  • ALEMANY BURCH, Reina
  • ESPUÑA MASO, Enric
  • RIERA PUJADAS, Pere
  • SAUBI ROCA, Narcis
Agents
  • DIAZ DE BUSTAMENTE Y TERMINEL, Isidoro
Priority Data
P 960016825.01.1996ES
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) NEW ATTENUATED STRAIN OF THE VIRUS CAUSING THE PORCINE REPRODUCTIVE RESPIRATORY SYNDROME (PRRS), VACCINES AND DIAGNOSTIC MEANS OBTAINABLE WITH SAID STRAIN, AND PRODUCTION PROCESS
(ES) NUEVA CEPA ATENUADA DEL VIRUS CAUSANTE DEL SINDROME RESPIRATORIO Y REPRODUCTIVO PORCINO (PRRS), LAS VACUNAS Y MEDIOS DE DIAGNOSTICO OBTENIBLES CON LA MISMA Y LOS PROCEDIMIENTOS PARA SU OBTENCION
(FR) NOUVELLE SOUCHE ATTENUEE DU VIRUS PROVOQUANT LE SYNDROME RESPIRATOIRE ET REPRODUCTIF PORCIN (PRRS), LES VACCINS ET LES MOYENS DE DIAGNOSTIC OBTENUS AVEC CETTE SOUCHE, ET LES PROCEDES POUR SON OBTENTION
Abstract
(EN)
The invention relates to a new attenuated strain (CNCM Institut Pasteur I-1642) of the virus causing the porcine disease known as porcine reproductive respiratory syndrome (PRRS), as well as to a process for the attenuation and replication of said strain by the use of a new clone obtained from monkey kidney cells MA-104 (CNCM Institut Pasteur I-1643). Due to its innocuousness for the suines and due to its high immunogenic activity, said new attenuated strain provides for the production of vaccines and diagnostic means which make possible an early diagnosis of PRRS and an efficient preventive treatment of said disease.
(ES)
Se describe una nueva cepa atenuada (CNCM Institut Pasteur I-1642) del virus causante de la enfermedad del ganado porcino conocida como síndrome respiratorio y reproductivo porcino (PRRS), así como un procedimiento de atenuación y replicación de la misma por medio del empleo de un nuevo clon obtenido a partir de células de riñón de mono MA-104 (CNCM Institut Pasteur I-1643). Debido a su inocuidad para los suidos y a su elevada actividad inmunogénica, la mencionada nueva cepa atenuada permite obtener vacunas y medios de diagnóstico que posibilitan un diagnóstico precoz del PRRS y un eficaz tratamiento preventivo de dicha enfermedad.
(FR)
L'invention décrit une nouvelle souche atténuée (CNCM Institut Pasteur I-1642) du virus provoquant la maladie porcine connue sous le nom de syndrome respiratoire et reproductif porcin (PRRS), ainsi qu'un procédé d'atténuation et de réplication de ladite souche au moyen d'un nouveau clone obtenu à partir de cellules de rein de singe MA-104 (CNCM Institut Pasteur I-1643). Compte tenu de son innocuité pour les suidés et de son intense activité immunogénique, cette nouvelle souche atténuée permet d'obtenir des vaccins et des moyens de diagnostic qui rendent possible un diagnostic précoce du PRRS et un traitement préventif efficace de cette maladie.
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