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1. WO1997027169 - (2-DIMETHYLPHENOXY-1-METHYLETHYL) ETHYLAMINE

Publication Number WO/1997/027169
Publication Date 31.07.1997
International Application No. PCT/EP1997/000135
International Filing Date 21.01.1997
Chapter 2 Demand Filed 10.07.1997
IPC
C07C 217/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
16the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
CPC
C07C 217/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
02having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
14the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
16the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
Applicants
  • F.HOFFMANN-LA ROCHE AG [CH]/[CH]
Inventors
  • BERGER, Jacob
  • FLIPPIN, Lee, Allen
  • HUNTER, John, Cureton
  • LOUGHHEAD, David, Garrett
  • WEIKERT, Robert, James
Agents
  • MAHE, Jean
Priority Data
60/011,04825.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) (2-DIMETHYLPHENOXY-1-METHYLETHYL) ETHYLAMINE
(FR) (2-DIMETHYLPHENOXY-1-METHYLETHYL)ETHYLAMINE
Abstract
(EN)
This invention relates to a compound of formula (I) namely [2-(2,6-dimethlphenoxy)-1-methylethyl]ethylamine and its pharmacetically acceptable salts thereof, to racemic and non-racemic mixtures thereof, and in particular to its $i((R))-enantiomer. The compound of Formula (I) is a sodium channel blocker, and thus exhibits useful pharmacological properties, especially utility for the alleviation of neuropathic pain.
(FR)
L'invention concerne un composé de la formule (I), à savoir, [2-(2,6-diméthylphénoxy)-1-méthyléthyl]éthylamine et les sels pharmaceutiquement acceptables de ce dernier, et des mélanges racémiques et non racémiques de celui-ci, et en particulier, son $i((R))-énantiomère. Le composé selon la formule (I) est un inhibiteur sodique, et présente ainsi des propriétés pharmacologiques utiles, en particulier, pour soulager les douleurs neuropathiques.
Also published as
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