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1. WO1997026278 - SYNTHETIC IL-10 ANALOGUES

Publication Number WO/1997/026278
Publication Date 24.07.1997
International Application No. PCT/DK1996/000029
International Filing Date 18.01.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 1/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
18for pancreatic disorders, e.g. pancreatic enzymes
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 14/5428
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
5428IL-10
Applicants
  • STEENO RESEARCH GROUP A/S [DK]/[DK] (AllExceptUS)
  • GRØNHØJ LARSEN, Christian [DK]/[DK] (UsOnly)
  • GESSER, Borbala [SE]/[DK] (UsOnly)
Inventors
  • GRØNHØJ LARSEN, Christian
  • GESSER, Borbala
Agents
  • PLOUGMANN, VINGTOFT & PARTNERS
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHETIC IL-10 ANALOGUES
(FR) ANALOGUES SYNTHETIQUES D'IL-10
Abstract
(EN)
The invention relates to use of a substance or polypeptide according to the formula: X1-X2-X3-Thr-X4-Lys-X5-Arg-X6 (SEQ ID NO:22), wherein X1 is Ala or Gly, X2 is Tyr or Phe, X3, X4 and X5 are independently selected from the group consisting of Met, Ile, Leu and Val; and X6 is selected from the group consisting of Asp, Gln and Glu, optionally at least one of X1, X2, X3, X4, X5 and X6 is independently substituted with non-natural or unusual amino acids and/or the peptide is cyclized and/or the peptide is stabilized and/or the amino terminal amino acid residue is acylated and/or the carboxy terminal amino acid residue is amidated, and peptidomimetics modelled on the basis of the above formula for the preparation of a pharmaceutical composition for the reduction of TNF$g(a) production. In particular, the invention relates to analogues of peptides of the above formula wherein at least one of X1, X2, X3, X4, X5 and X6 is independently substituted with non-natural or unusual amino acids and/or the peptide is cyclized and/or the peptide is stabilized and/or the amino terminal amino acid residue is acylated and/or the carboxy terminal amino acid residue is amidated, and peptidomimetics modelled on the basis of the above formula.
(FR)
L'invention concerne l'utilisation d'une substance ou d'un polypeptide selon la formule X1-X2-X3-Thr-X4-Lys-X5-Arg-X6 (SEQ ID NO:22), dans laquelle X1 représente Ala ou Gly, X2 représente Tyr ou Phe, X3, X4 et X5 sont sélectionnés indépendamment dans le groupe constitué de Met, Ile, Leu et Val; et X6 est choisi dans le groupe constitué de Asp, Gln and Glu, facultativement au moins un des X1, X2, X3, X4, X5 et X6 est indépendamment substitué par des acides aminés non naturels ou inhabituels ou le peptide est cyclisé et/ou le peptide est stabilisé et/ou le reste d'acide aminé amino terminal est acylé et/ou le reste d'acide aminé carboxy terminal est aminé et la peptidomimétique est modelée sur la base de la formule précitée pour la préparation d'une composition pharmaceutique destinée à réduire la production du facteur TNF$g(a). L'invention concerne notamment des analogues de peptides de la formule précitée dans laquelle au moins un des X1, X2, X3, X4, X5 et X6 est substitué indépendamment par des acides aminés non naturels ou inhabituels et/ou le peptide est cyclisé et/ou le peptide est stabilisé et/ou le reste d'acide aminé amino terminal est acylé et/ou le reste d'acide aminé carboxy terminal est amidé, et la peptidomimétique modelée sur la base de la formule précitée.
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