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1. WO1997026072 - SUBATMOSPHERIC, VARIABLE PRESSURE SAMPLE DELIVERY CHAMBER FOR ELECTROSPRAY IONIZATION/MASS SPECTROMETRY AND OTHER APPLICATIONS

Publication Number WO/1997/026072
Publication Date 24.07.1997
International Application No. PCT/US1997/000733
International Filing Date 17.01.1997
Chapter 2 Demand Filed 18.08.1997
IPC
G01N 27/447 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
H01J 49/04 2006.01
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
G01N 30/28 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
28Control of physical parameters of the fluid carrier
G01N 30/72 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
CPC
G01N 2030/285
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
28Control of physical parameters of the fluid carrier
285electrically driven carrier
G01N 27/44717
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
44704Details; Accessories
44717Arrangements for investigating the separated zones, e.g. localising zones
G01N 30/7266
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
62Detectors specially adapted therefor
72Mass spectrometers
7233interfaced to liquid or supercritical fluid chromatograph
724Nebulising, aerosol formation or ionisation
7266by electric field, e.g. electrospray
H01J 49/045
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
0431for liquid samples
0445with means for introducing as a spray, a jet or an aerosol
045with means for using a nebulising gas, i.e. pneumatically assisted
H01J 49/165
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
10Ion sources; Ion guns
16using surface ionisation, e.g. field-, thermionic- or photo-emission
165Electrospray ionisation
Applicants
  • NORTHEASTERN UNIVERSITY [US]/[US]
Inventors
  • KARGER, Barry, L.
  • FORET, Frantisek
  • KIRBY, Daniel, P.
Agents
  • SCHURGIN, Stanley, M.
Priority Data
60/010,24219.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SUBATMOSPHERIC, VARIABLE PRESSURE SAMPLE DELIVERY CHAMBER FOR ELECTROSPRAY IONIZATION/MASS SPECTROMETRY AND OTHER APPLICATIONS
(FR) ENCEINTE DE REPARTITION D'ECHANTILLONS, SUBATMOSPHERIQUE ET A PRESSION VARIABLE, AUX FINS D'UNE IONISATION PAR ELECTRO-PULVERISATION/SPECTROMETRIE DE MASSE ET D'AUTRES APPLICATIONS
Abstract
(EN)
A subatmospheric, variable pressure sample delivery chamber (2), useful as an electrospray ionization device for introducing a sample into a mass spectrometer (9) or as a sample delivery device for delivery of a sample to a collection device (74) at subatmospheric pressures, is disclosed. The sample delivery chamber (2) is configured to maintain an operating pressure between 1 and 750 Torr, preferably between 50 and 700 Torr. The chamber has an inlet port (4) for introduction of a gas and an exit port (6) capable of being coupled either to a sampling orifice (8) for an analytical device, usually a mass spectrometer (9), or directly to a pump for removal of gas. A sample delivery device (22) extends from outside the chamber into the interior of the chamber (2). The inlet end (12) of the sample delivey device is capable of receiving a sample and the exit end of the sample delivery device (14) is aligned with the exit port (6) of the chamber, if the sample is to be delivered to an external analytical device, or aligned with the collection device (74), for direct collection of the sample.
(FR)
L'invention porte sur une enceinte (2) de répartition d'échantillons subatmosphérique, à pression variable, utilisable en tant que dispositif d'ionisation par électro-pulvérisation pour l'introduction d'un échantillon dans un spectromètre de masse ou en tant que dispositif de répartition d'échantillons à des pressions subatmosphériques. L'enceinte (2) de répartition d'échantillons est configurée de manière à maintenir une pression de fonctionnement entre 1 et 750 torrs, de préférence entre 50 et 700 torrs. Cette enceinte comporte un orifice d'admission (4) destiné à l'introduction d'un gaz et un orifice de sortie (6), susceptible de couplage à un orifice d'échantillonnage (8) pour un dispositif d'analyse, en règle générale, un spectromètre de masse (9) ou, directement, à une pompe d'évacuation du gaz. L'extrémité d'admission du dispositif de répartition d'échantillon (22) est en mesure de recevoir un échantillon et son extrémité de sortie (6) est alignée avec l'orifice de sortie de l'enceinte, si l'échantillon doit être acheminé jusqu'à un dispositif d'analyse extérieur, ou alignée avec le dispositif de collecte aux fins d'une collecte directe de l'échantillon.
Also published as
Latest bibliographic data on file with the International Bureau