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1. WO1997026017 - PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THEIR USE IN NMR DIAGNOSTICS

Publication Number WO/1997/026017
Publication Date 24.07.1997
International Application No. PCT/EP1997/000209
International Filing Date 16.01.1997
Chapter 2 Demand Filed 02.07.1997
IPC
A61K 49/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
C07C 229/76 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
76Metal complexes of amino carboxylic acids
C07C 237/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
237Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
02having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
04the carbon skeleton being acyclic and saturated
10having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
C07D 257/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
C07D 295/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
22with hetero atoms directly attached to ring nitrogen atoms
26Sulfur atoms
CPC
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 49/0004
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
B65D 25/16
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
25Details of other kinds or types of rigid or semi-rigid containers
14Linings or internal coatings
16Loose, or loosely-attached, linings
B65D 47/0847
BPERFORMING OPERATIONS; TRANSPORTING
65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
47Closures with filling and discharging, or with discharging, devices
04Closures with discharging devices other than pumps
06with pouring spouts or tubes; with discharge nozzles or passages
08having articulated or hinged closures
0804integrally formed with the base element provided with the spout or discharge passage
0833Hinges without elastic bias
0847located within a flat surface of the base element
Applicants
  • SCHERING AKTIENGESELLSCHAFT [DE]/[DE]
Inventors
  • PLATZEK, Johannes
  • NIEDBALLA, Ulrich
  • RADÜCHEL, Bernd
  • SCHLECKER, Wolfgang
  • WEINMANN, Hanns-Joachim
  • FRENZEL, Thomas
  • MISSELWITZ, Bernd
  • EBERT, Wolfgang
Priority Data
196 03 033.119.01.1996DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) PERFLUORALKYLHALTIGE METALLKOMPLEXE UND IHRE VERWENDUNG IN DER NMR-DIAGNOSTIK
(EN) PERFLUOROALKYL-CONTAINING METAL COMPLEXES AND THEIR USE IN NMR DIAGNOSTICS
(FR) COMPLEXES METALLIQUES CONTENANT DU PERFLUOROALKYLE ET LEUR UTILISATION DANS LE DIAGNOSTIC PAR RMN
Abstract
(DE)
Die Erfindung betrifft neue, monomere, perfluoralkylsubstituierte Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in Diagnostik und Therapie. Die erfindungsgemäßen Verbindungen sind insbesondere als in vivo-Kontrastmittel in der Kernspintomographie (MRT) geeignet. Bevorzugt können sie als blood-pool-agents und als Lymphographika eingesetzt werden.
(EN)
The invention concerns new monomer perfluoroalkyl-substituted metal complexes, a process for their production, and their use in diagnostics and therapy. The compounds according to the invention to the invention are particularly suited for use as in vivo contrast agents in nuclear spin resonance tomography (MRT). They can be preferably used as blood pool agents and contrast agents for lymphography.
(FR)
L'invention concerne de nouveaux complexes métalliques monomères, à substitution perfluoroalkyle, leur procédé de préparation et leur utilisation diagnostique et thérapeutique. Ces composés sont particulièrement appropriés pour être utilisés en tant qu'agents de contraste in vivo en imagerie par résonance magnétique nucléaire. Ils peuvent être employés de préférence en tant qu'agents de marquage sanguin ('blood-pool agents') et en tant qu'agents de contraste pour la lymphographie.
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