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1. WO1997025979 - GASTROINTESTINAL DRUG DELIVERY SYSTEM

Publication Number WO/1997/025979
Publication Date 24.07.1997
International Application No. PCT/IB1997/000037
International Filing Date 17.01.1997
Chapter 2 Demand Filed 15.08.1997
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
CPC
A61K 9/205
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2022Organic macromolecular compounds
205Polysaccharides, e.g. alginate, gums; Cyclodextrin
A61K 9/2846
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
284obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
2846Poly(meth)acrylates
A61K 9/286
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
286Polysaccharides, e.g. gums; Cyclodextrin
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
Applicants
  • PERIO PRODUCTS LTD. [IL]/[IL]
Inventors
  • LERNER, E., Itzhak
  • FLASHNER, Moshe
  • PENHASI, Adel
Agents
  • WHITE, Martin Paul
  • CIMBALA, Michele, A.
Priority Data
08/588,24718.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GASTROINTESTINAL DRUG DELIVERY SYSTEM
(FR) SYSTEME POUR L'ADMINISTRATION DE MEDICAMENTS DANS LE TUBE DIGESTIF
Abstract
(EN)
A gastrointestinal delivery system is provided. The system comprises a drug in combination with a core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded. When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. These channels allow the release of drug from the core into the gastrointestinal tract. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location- and time-dependent manner.
(FR)
Système d'administration pour le tube digestif, comportant un médicament associé à une matière de noyau, le noyau étant entouré d'une matière d'enrobage non hydrosoluble ou relativement peu hydrosoluble dans laquelle est noyée une matière particulaire non hydrosoluble. Lorsque le dispositif d'administration pénètre dans le tube digestif, la matière particulaire absorbe du liquide de manière à former des passages reliant le noyau renfermant le médicament à l'extérieur du dispositif d'administration. Ces passages permettent de libérer le médicament dans le tube digestif à partir du noyau. On peut déterminer avec précision l'endroit où le médicament sera libéré en modulant les paramètres du dispositif, à savoir, par exemple, la matière de noyau, la matière servant d'excipient dans l'enrobage, et la matière particulaire. On a également prévu un procédé pour la mise en oeuvre du dispositif dans le traitement des maladies par libération de médicaments dans le tube digestif, dans un endroit précis et à un instant précis.
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