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1. WO1997025618 - CYTOPLASMIC MODULATORS OF INTEGRIN BINDING/SIGNALLING

Publication Number WO/1997/025618
Publication Date 17.07.1997
International Application No. PCT/US1997/000071
International Filing Date 03.01.1997
IPC
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
G01N 33/5008
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
G01N 33/502
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
502for testing non-proliferative effects
Applicants
  • ICOS CORPORATION [US]/[US]
Inventors
  • STAUNTON, Donald, E.
  • HARRIS, Edith, A., Salot
Agents
  • BORUN, Michael, F.
Priority Data
08/583,31805.01.1996US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYTOPLASMIC MODULATORS OF INTEGRIN BINDING/SIGNALLING
(FR) MODULATEURS CYTOPLASMIQUES DE LIAISON A L'INTEGRINE ET/OU DE SIGNALISATION D'INTEGRINE
Abstract
(EN)
The present invention relates to methods to identify modulators of integrin binding and/or signalling activity. Specifically, the invention relates to a method to identify compounds which can alter the interaction between the cytoplasmic domain of a $g(b)1 integrin and a proteasome subunit protein.
(FR)
Cette invention porte sur des procédés permettant d'identifier des modulateurs de liaison à l'intégrine et/ou d'activité signalisatrice de celle-ci. Elle concerne, notamment, un procédé permettant de recenser des composés susceptibles de modifier l'interaction existant entre le domaine cytoplasmique d'une intégrine $g(b)1 et une protéine de sous-unité de protéasome.
Also published as
Latest bibliographic data on file with the International Bureau