Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997024359 - NOVEL CEPHALOSPORIN DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

Publication Number WO/1997/024359
Publication Date 10.07.1997
International Application No. PCT/KR1996/000255
International Filing Date 27.12.1996
Chapter 2 Demand Filed 16.07.1997
IPC
C07D 501/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07D 501/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of bulk chemicals
55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • IL-DONG PHARM. CO., LTD. [KR]/[KR] (AllExceptUS)
  • KIM, Kee-Won [KR]/[KR] (UsOnly)
  • KANG, Jae-Hoon [KR]/[KR] (UsOnly)
  • YU, Dong-Sik [KR]/[KR] (UsOnly)
  • JANG, Moo-Soo [KR]/[KR] (UsOnly)
  • YU, Seung-Woo [KR]/[KR] (UsOnly)
Inventors
  • KIM, Kee-Won
  • KANG, Jae-Hoon
  • YU, Dong-Sik
  • JANG, Moo-Soo
  • YU, Seung-Woo
Agents
  • PARK, Sa, Ryong
Priority Data
1995/6149828.12.1995KR
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL CEPHALOSPORIN DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
(FR) NOUVEAUX DERIVES DE CEPHALOSPORINES ET LEURS PROCEDES DE PREPARATION
Abstract
(EN)
The present invention relates to novel cephalosporin derivatives of formula (I) and pharmaceutically acceptable non-toxic salts thereof, to processes for preparing these compounds and to pharmaceutical compositions containing the same as active ingredients, which have broad antibacterial activities against both Gram-positive and Gram-negative bacteria, wherein R1a is a hydrogen atom or an amino protecting group; R1b is a hydrogen atom, C1-4 alkyl group, C2-4 alkenyl group, C2-4 alkynyl group, fluoro-substituted C1-3 alkyl group or a substituted or unsubstituted carboxyalkyl group; Q is CH or N; R2 and R3 may be the same or different and mean individually a group selected from C1-3 alkyl group, C2-4 alkenyl group, C2-4 alkynyl group and hydroxyl-substituted C1-3 alkyl group; and R4 is (a), (b), (c) or (d) wherein R5 is a hydrogen atom, C1-3 alkyl group or a hydroxyl-substituted C1-3 alkyl group; R6 is a hydrogen atom, C1-3 alkyl group, C2-4 alkenyl group or an amino group; R7 is a C1-3 alkyl group or a hydroxyl-substituted C1-3 alkyl group; Y is O or S or N; and Z is a hydrogen atom, C1-3 alkyl group, chlorine or fluorine atom.
(FR)
On décrit de nouveaux dérivés de céphalosporines, correspondant à la formule (I), et leurs sels non toxiques pharmacologiquement acceptables, des procédés permettant de les préparer et des compositions pharmaceutiques les contenant à titre d'ingrédients actifs présentant une activité anti-bactérienne large contre des bactéries à gram positif et négatif. Dans la formule (I), R1a représente un atome d'hydrogène ou un groupe de protection amino; R1b représente un atome d'hydrogène, un groupe C1-4 alkyle, un groupe C2-4 alcényle, un groupe C2-4 alkynyle, un groupe C1-3 alkyle fluoro-substitué ou un groupe carboxyalkyle, substitué ou non; Q représente CH ou N; R2 et R3, identiques ou différents, représentent individuellement un groupe choisi parmi C1-3 alkyle, C2-4 alcényle, C2-4 alkynyle et C1-3 alkyle hydroxyle-substitué; et R4 représente (a), (b), (c) ou (d) où R5 représente un atome d'hydrogène, un groupe C1-3 alkyle ou un groupe C1-3 alkyle hydroxyle-substitué; R6 représente un atome d'hydrogène, un groupe C1-3 alkyle, un groupe C2-4 alcényle ou un groupe amino; R7 représente un groupe C1-3 alkyle ou un groupe C1-3 alkyle hydroxyle-substitué; Y représente O, S ou N; et Z représente un atome d'hydrogène, un groupe C1-3 alkyle, ou un atome de chlore ou de fluor.
Latest bibliographic data on file with the International Bureau