Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997024356 - 1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-(FUSED IMIDAZOLE)-PIPERIDINE DERIVATIVES

Publication Number WO/1997/024356
Publication Date 10.07.1997
International Application No. PCT/EP1996/005885
International Filing Date 20.12.1996
Chapter 2 Demand Filed 30.05.1997
IPC
C07D 471/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 471/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
20Spiro-condensed systems
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C07D 495/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 13/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
10of the bladder
Applicants
  • JANSSEN PHARMACEUTICA N.V. [BE]/[BE] (AllExceptUS)
  • JANSSENS, Frans, Eduard [BE]/[BE] (UsOnly)
  • LEENAERTS, Joseph, Elisabeth [BE]/[BE] (UsOnly)
  • VAN ROOSBROECK, Yves, Emiel, Maria [BE]/[BE] (UsOnly)
Inventors
  • JANSSENS, Frans, Eduard
  • LEENAERTS, Joseph, Elisabeth
  • VAN ROOSBROECK, Yves, Emiel, Maria
Agents
  • QUAGHEBEUR, Luc
Priority Data
95.203.652.327.12.1995EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 1-(1,2-DISUBSTITUTED PIPERIDINYL)-4-(FUSED IMIDAZOLE)-PIPERIDINE DERIVATIVES
(FR) DERIVES 1-(PIPERIDINYL 1,2-DISUBSTITUE)-(4-IMIDAZOLE FUSIONNE)-PIPERIDINE
Abstract
(EN)
This invention concerns the compounds of formula (I), the $i(N)-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is 0, 1 or 2; m is 1 or 2, provided that if m is 2, then n is 1; =Q is =O or =NR3; X is a covalent bond or -O-, -S-, -NR3-; R1 is Ar1, Ar1C1-6alkyl or di(Ar1)C1-6alkyl, wherein each C1-6alkyl group is optionally substituted; R2 is Ar2, Ar2C1-6alkyl, Het or HetC1-6 alkyl; R3 is hydrogen or C1-6alkyl; L is a piperidine derivative of formula (a-1) or a spiro piperidine derivative of formula (a-2); Ar1 is phenyl or substituted phenyl; Ar2 is naphtalenyl; phenyl or substituted phenyl; and Het is a monocyclic or bicyclic heterocycle; each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom; as substance P antagonists; their preparation, compositions containing them and their use as a medicine.
(FR)
L'invention concerne des composés de la formule (I), les dérivés oxyde d'azote de ces composés et leurs sels d'addition acceptables sur le plan pharmaceutique, ainsi que leurs isomères stéréochimiques. Dans cette formule, n est 0, 1 ou 2; m est 1 ou 2, à condition que, si m est 2, alors n est 1; =Q est =O ou =NR3-; X est une liaison covalente ou -O-, -S-, -NR3-; R1 est Ar1, Ar1C1-6alkyle ou di(Ar1)C1-6alkyle, où chaque groupe C1-6alkyle est éventuellement substitué; R2 est Ar2, Ar2C1-6alkyle, Het ou HetC1-6alkyle; R3 est un hydrogène ou un C1-6alkyle; L est un dérivé pipéridine de la formule (a-1) ou un dérivé spiro de la pipéridine de la formule (a-2); Ar1 est un phényle éventuellement substitué; Ar2 est un naphtalényle ou un phényle éventuellement substitué; et Het est un composé hétéromonocyclique ou hétérobicyclique, éventuellement substitué sur un atome de carbone. Les composés en question sont utiles comme antagonistes de la substance P. L'invention concerne également la préparation de ces composés, des formulations les contenant et leur utilisation comme médicament.
Latest bibliographic data on file with the International Bureau