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1. WO1997024354 - SUBSTITUTED 6-R-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS ANAESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM

Publication Number WO/1997/024354
Publication Date 10.07.1997
International Application No. PCT/RU1995/000285
International Filing Date 28.12.1995
Chapter 2 Demand Filed 25.07.1997
IPC
C07D 417/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 23/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23Anaesthetics
C07D 417/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • THE PROCTER & GAMBLE COMPANY [US]/[US] (AllExceptUS)
  • NAUCHNO-TEKHNOLOGICHESKOE PREDPRIYATIE 'LIGAND' (TOVARISCHESTVO S OGRANICHENNOI OTVETSTVENNOSTJU) [RU]/[RU] (AllExceptUS)
  • CHUPAKHIN, Oleg Nikolaevich [RU]/[RU] (UsOnly)
  • SIDOROVA, Larisa Petrovna [RU]/[RU] (UsOnly)
  • TARAKHTY, Emma Afanasievna [RU]/[RU] (UsOnly)
  • NOVIKOVA, Antonina Petrovna [RU]/[RU] (UsOnly)
  • PEROVA, Natalya Mikhailovna [RU]/[RU] (UsOnly)
  • VINOGRADOV, Valentin Antonovich [RU]/[RU] (UsOnly)
  • VAN GINKEL, Michiel, Franciscus [NL]/[NL] (UsOnly)
Inventors
  • CHUPAKHIN, Oleg Nikolaevich
  • SIDOROVA, Larisa Petrovna
  • TARAKHTY, Emma Afanasievna
  • NOVIKOVA, Antonina Petrovna
  • PEROVA, Natalya Mikhailovna
  • VINOGRADOV, Valentin Antonovich
  • VAN GINKEL, Michiel, Franciscus
Agents
  • SOJUZPATENT
Priority Data
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) SUBSTITUTED 6-R-1,3,4-THIADIAZINE-2-AMINES, THE USE THEREOF AS ANAESTHETISING, CARDIOVASCULAR AND HYPOMETABOLIC AGENTS, AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM
(FR) 6-R-1,3,4-THIADIAZINE-2-AMINES SUBSTITUES, LEUR UTILISATION EN QUALITE D'AGENTS ANESTHESIQUES, CARDIO-VASCULAIRES ET HYPOMETABOLIQUES, ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
Abstract
(EN)
The disclosure relates to substituted 6-R-1,3,4-thiadiazine-2-amines of general formula (I), in which Ar stands for phenyl which may be substituted with one or more atoms of chlorine, bromine, C1-C4 alkoxy or C1-C4 alkyl groups; R1 and R2 each independently of one another represent a hydrogen atom or a C1-C4 alkyl residue; and R3 and R4 are independently selected from C1-C4 alkyl groups. Also disclosed are the pharmacologically acceptable salts of these compounds, their use as anaesthetising, cardiovascular and hypometabolic agents and a pharmaceutical composition containing them.
(FR)
Cette invention concerne des 6-R-1,3,4-thiadiazine-2-amines substitués correspondant à la formule générale (I) où Ar représente un phényle pouvant être substitué par un ou plusieurs atomes de chlore, de brome ou, encore, par des groupes alcoxy C1-C4 ou des groupes alkyles C1-C4; R1 et R2 représentent indépendamment un atome d'hydrogène ou un résidu alkyle C1-C4; et R3 et R4 sont choisis indépendamment parmi des groupes alkyles C1-C4. Cette invention concerne également les sels de ces composés acceptables sur le plan pharmaceutique, leur utilisation en qualité d'agents anesthésiques, cardio-vasculaires et hypométaboliques, ainsi que des compositions pharmaceutiques les contenant.
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