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1. WO1997024143 - CYTOTOXIC AGENTS

Publication Number WO/1997/024143
Publication Date 10.07.1997
International Application No. PCT/GB1996/003254
International Filing Date 27.12.1996
Chapter 2 Demand Filed 02.05.1997
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 47/6899
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6891Pre-targeting systems involving an antibody for targeting specific cells
6899Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • AEPACT LIMITED [GB]/[GB] (AllExceptUS)
  • BAGSHAWE, Kenneth, Dawson [GB]/[GB] (UsOnly)
  • BURKE, Philip, John [GB]/[GB] (UsOnly)
Inventors
  • BAGSHAWE, Kenneth, Dawson
  • BURKE, Philip, John
Agents
  • BASSETT, Richard
Priority Data
009,36129.12.1995US
2,168,68002.02.1996CA
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYTOTOXIC AGENTS
(FR) AGENTS CYTOTOXIQUES
Abstract
(EN)
A therapeutic system for destroying a target cell within a host having a vascular compartment, the system comprising: (a) a compound comprising a target cell-specific portion and a portion which will convert a selected substantially non-cytotoxic substance into a cytotoxic substance; and (b) said substantially non-cytotoxic substance, wherein at least the said portion of compound (a) capable of said conversion is, following administration to the host, internalised into said target cell. Preferably, the portion which converts said substantially non-cytotoxic substance into a cytotoxic substance requires a factor which is present in sufficient concentration within the target cell for the said portion to effect conversion of said substantially non-cytotoxic substance into a cytotoxic substance and which factor is not present in sufficient concentration within the blood of the vascular compartment for the said portion to effect said conversion.
(FR)
L'invention concerne un système thérapeutique pour détruire une cellule cible dans un hôte présentant un compartiment vasculaire, le système comprenant : (a) un composé comprenant une partie spécifique d'une cellule cible et une partie qui convertit une substance choisie sensiblement non cytotoxique, en une substance cytotoxique; et (b) ladite substance sensiblement non cytotoxique, où au moins la partie (a) de composé capable de ladite conversion est, après l'administration à l'hôte, assimilée par ladite cellule cible. De préférence, la partie qui convertit la substance sensiblement non cytotoxique en une substance cytotoxique nécessite un facteur qui est présent à une concentration suffisante dans la cellule cible pour que cette partie puisse réaliser la conversion de la substance sensiblement non cytotoxique, en substance cytotoxique. Ce facteur n'est pas présent dans le sang et dans le compartiment vasculaire en une concentration suffisante pour que cette partie effectue cette conversion.
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