Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997023639 - PROCESS FOR PRODUCING BIOLOGICALLY ACTIVE FUSED PROTEINS

Publication Number WO/1997/023639
Publication Date 03.07.1997
International Application No. PCT/JP1996/003742
International Filing Date 20.12.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/54 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
C07K 14/55 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins (IL)
55IL-2
C12N 15/62 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
62DNA sequences coding for fusion proteins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/5434
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
5434IL-12
C07K 14/55
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
52Cytokines; Lymphokines; Interferons
54Interleukins [IL]
55IL-2
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C07K 2319/75
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
70containing domain for protein-protein interaction
74containing a fusion for binding to a cell surface receptor
75containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Applicants
  • TORAY INDUSTRIES, INC. [JP]/[JP] (AllExceptUS)
  • TORAY RESEARCH CENTER, INC. [JP]/[JP] (AllExceptUS)
  • NAKATANI, Izumi [JP]/[JP] (UsOnly)
  • TOMURA, Michio [JP]/[JP] (UsOnly)
  • KANAI, Shozo [JP]/[JP] (UsOnly)
  • FUJIWARA, Hiromi [JP]/[JP] (UsOnly)
  • AKIYAMA, Hideo [JP]/[JP] (UsOnly)
Inventors
  • NAKATANI, Izumi
  • TOMURA, Michio
  • KANAI, Shozo
  • FUJIWARA, Hiromi
  • AKIYAMA, Hideo
Agents
  • KAGAWA, Mikio
Priority Data
7/33487522.12.1995JP
7/35036422.12.1995JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PROCESS FOR PRODUCING BIOLOGICALLY ACTIVE FUSED PROTEINS
(FR) PROCEDE DE PRODUCTION DE PROTEINES FUSIONNEES BIOLOGIQUEMENT ACTIVES
Abstract
(EN)
A process for producing biologically active fused proteins whereby novel biologically active fused proteins usable as a remedy or a diagnostic drug or applicable to gene therapy can be efficiently produced by appropriately selecting the optimum linker polypeptide. This process comprises incubating transformants obtained by the transformation by expression vectors which contain the DNA sequences encoding the amino acid sequences of proteins represented by the following formula: A-X-B wherein A and B represent respectively the subunits of a dimer protein or biologically active proteins and may be the same; and X represents a linker polypeptide.
(FR)
L'invention porte sur un procédé de production de protéines fusionnées, biologiquement actives, pouvant servir de remède ou d'agent diagnostique ou s'appliquer à la thérapie génique, et s'obtenant par une sélection du polypeptide de liaison le mieux approprié. Ledit procédé consiste à incuber des transformants obtenus par la transformation de vecteurs d'expression contenant des séquences d'ADN codant pour les séquences d'acides aminés de protéines de formule A-X-B où A et B, qui peuvent être identiques, représentent respectivement les sous-unités d'une protéine dimère ou de protéines biologiquement actives, et X, le polypeptide de liaison.
Also published as
Latest bibliographic data on file with the International Bureau