Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997023494 - CARBOHYDRATE CONJUGATED BIO-ACTIVE COMPOUNDS

Publication Number WO/1997/023494
Publication Date 03.07.1997
International Application No. PCT/US1996/019838
International Filing Date 12.12.1996
Chapter 2 Demand Filed 23.07.1997
IPC
C07H 9/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02the hetero ring containing only oxygen as ring hetero atoms
04Cyclic acetals
C07H 19/056 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
056Triazole or tetrazole radicals
C07H 19/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
06Pyrimidine radicals
CPC
A61K 47/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
549Sugars, nucleosides, nucleotides or nucleic acids
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07H 19/056
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
056Triazole or tetrazole radicals
Applicants
  • ICN PHARMACEUTICALS [US]/[US] (AllExceptUS)
  • MILJKOVIC, Dusan [YU]/[US] (UsOnly)
  • PIETRZKOWSKI, Zbigniew [PL]/[US] (UsOnly)
  • GUNIC, Esmir [BA]/[US] (UsOnly)
  • SEIFERT, Wilfried [DE]/[US] (UsOnly)
Inventors
  • MILJKOVIC, Dusan
  • PIETRZKOWSKI, Zbigniew
  • GUNIC, Esmir
  • SEIFERT, Wilfried
Agents
  • FISH, Robert, D.
Priority Data
08/576,81721.12.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CARBOHYDRATE CONJUGATED BIO-ACTIVE COMPOUNDS
(FR) COMPOSES BIOACTIFS CONJUGUES A DES HYDRATES DE CARBONE
Abstract
(EN)
Methods and compositions are provided which increase the cellular uptake of bioactive materials by covalently bonding such compounds to carbohydrate moieties through chemical linkers using other than glycosidic bonds. Numerous carbohydrates, linkers and bioactive materials can be joined in this way to form novel compositions, which are collectively referred to herein as glinkosides. Preferred glinkosides are preferentially taken up by glucose receptor and/or other cellular receptors, and once inside the cells, the glinkosides are cleaved into a sugar, a linker or linker fragments, and a biologically active compound. Various aspects of the invention include processes for synthesizing glinkosides, glinkoside compositions, and methods of treating diseases using glinkosides.
(FR)
L'invention concerne des procédés et des compositions qui augmentent la pénétration intracellulaire de matériaux bioactifs en liant ces composés, par une liaison covalente, à des groupes hydrates de carbone par l'intermédiaire d'éléments de liaison chimiques utilisant d'autres liaisons que les liaisons glucosidiques. De nombreux hydrates de carbone, éléments de liaison et matières bioactives peuvent être liés ainsi pour constituer de nouvelles compositions, nommées ici collectivement 'glinkosides'. Les glinkosides préférés sont de préférence pris par les récepteurs du glucose et/ou d'autres récepteurs cellulaires et, une fois à l'intérieur des cellules, ils sont clivés de façon à donner un sucre, un élément de liaison ou des fragments d'éléments de liaison, et un composé biologiquement actif. Parmi les différents aspects de l'invention, on trouve des procédés permettant de synthétiser des glinkosides, des compostions de glinkosides, ainsi que des procédés permettant de traiter des maladies par lesdits glinkosides.
Latest bibliographic data on file with the International Bureau