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1. WO1997023482 - 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE DERIVATIVES

Publication Number WO/1997/023482
Publication Date 03.07.1997
International Application No. PCT/IB1996/001192
International Filing Date 06.11.1996
Chapter 2 Demand Filed 20.05.1997
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
A61P 1/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61P 25/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applicants
  • PFIZER INC. [US]/[US] (AllExceptUS)
  • SANNER, Mark, A. [US]/[US] (UsOnly)
Inventors
  • SANNER, Mark, A.
Agents
  • SPIEGEL, Allen, J.
Priority Data
60/008,98821.12.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 2,7-SUBSTITUTED OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE DERIVATIVES
(FR) DERIVES DE 2,7-OCTAHYDRO SUBSTITUE-PYRROLO[1,2-A]PYRAZINE
Abstract
(EN)
This invention relates to compounds of formula (I), wherein R1 is phenyl, naphthyl, benzoxazolonyl, indolyl, indolonyl, benzimidazolyl, quinolyl, furyl, benzofuryl, thienyl, benzothienyl, oxazolyl, benzoxazolyl; R2 is H or (C1-C6)alkyl; R3 is phenyl, pyridinyl, pyrimidinyl, pyrazinyl, or pyridazinyl; X is O, S, SO, SO2, NR4, C=O, CH(OH), CHR4, (a), (b), (c), or (d); m is 0, 1 or 2; n is 0, 1 or 2. The compounds of this invention are ligands for dopamine receptor subtypes, especially the dopamine D4 receptor, and are therefore useful in the treatment of disorders of the dopamine system.
(FR)
Cette invention se rapporte à des composés représentés par la formule (I) dans laquelle R1 est phényle, naphthyle, benzoxazolonyle, indolyle, indolonyle, benzimidazolyle, quinolyle, furyle, benzofuryle, thiényle, benzothiényle, oxazolyle, benzoxazolyle, R2 est H ou alkyle (C1-C6), R3 est phényle, pyridinyle, pyrimidinyle, pyrazinyle ou pyridazinyle, X est O, S, SO, SO2, NR4, C=O, CH(OH), CHR4 ou un des composés représentés par les formules (a), (b), (c) ou (d), m est égal à 0,1 ou 2 et n est égal à 0,1 ou 2. Les composés de cette invention sont des ligands des sous-types de récepteurs de la dopamine, en particulier du récepteur de la dopamine D4, et ils s'avèrent par conséquent utiles s'agissant du traitement des troubles du système dopaminergique.
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