Processing

Please wait...

Settings

Settings

Goto Application

1. WO1997023453 - 17-SIDE CHAIN ALKYNYL-AND 20-OXOPREGNA-DERIVATIVES OF VITAMIN D, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREOF

Publication Number WO/1997/023453
Publication Date 03.07.1997
International Application No. PCT/GB1996/003218
International Filing Date 23.12.1996
Chapter 2 Demand Filed 21.07.1997
IPC
C07C 401/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
401Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopentaphenanthrene or analogues obtained by chemical preparation without irradiation
CPC
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07C 401/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
401Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
Applicants
  • MARSDEN, John, Christopher [GB]/[GB] (GB)
  • RESEARCH INSTITUTE FOR MEDICINE AND CHEMISTRY, INC. [US]/[US] (AllExceptUS)
  • HESSE, Robert, Henry [US]/[US] (UsOnly)
  • PECHET, Maurice, Murdoch [US]/[US] (UsOnly)
  • SETTY, Sundara, Katugam, Srinivasasetty [IN]/[US] (UsOnly)
Inventors
  • HESSE, Robert, Henry
  • PECHET, Maurice, Murdoch
  • SETTY, Sundara, Katugam, Srinivasasetty
Agents
  • MARSDEN, John, Christopher
Priority Data
9526208.521.12.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 17-SIDE CHAIN ALKYNYL-AND 20-OXOPREGNA-DERIVATIVES OF VITAMIN D, METHODS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THEREOF
(FR) DERIVES DE 17-ALKYNYLE DE CHAINE LATERALE -ET-20-OXOPREGNACALCIFEROL DE VITAMINE D, LEURS PROCEDES DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES RESULTANTES
Abstract
(EN)
1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R1 is hydroxyl or lower alkoxy and R2 is optionally hydroxylated or lower alkoxylated lower alkynyl or R1 is C(RA) (RB)CH3 where RA is optionally hydroxylated or lower alkoxylated lower alkynyl and RB is hydroxyl or lower alkoxy or RA and RB together represent oxo and R2 is hydrogen, hydroxyl or lower alkoxy, and R3 and R4 represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents.
(FR)
Dérivés de 1-hydroxy pregnacalciferol représentés par la formule (I) et leurs 5,6-trans isomères correspondants, dans laquelle R1 représente hydroxyle ou alcoxy inférieur et R2 représente alkynyle inférieur éventuellement hydroxylé ou alcoxylé inférieur ou R1 représente C(RA) (RB)CH3, où RA représente alkynyle inférieur éventuellement hydroxylé ou alcoxylé inférieur et RB représente hydroxyle ou alcoxy inférieur ou RA et RB ensemble représentent oxo et R2 représente hydrogène, hydroxyle ou alcoxy inférieur et R3 et R4 représentent des atomes d'hydrogène. Ces dérivés présentent une activité anti-progestérone et peuvent être utiles en tant qu'agents anti-néoplasiques, anti-fertilité, anti-prolifératifs, immunosuppresseurs et/ou anti-inflammatoires.
Latest bibliographic data on file with the International Bureau