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1. (WO1997022699) MURINE MONOCLONAL ANTI-IDIOTYPE ANTIBODY 11D10 AN METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/022699    International Application No.:    PCT/US1996/020757
Publication Date: 26.06.1997 International Filing Date: 19.12.1996
Chapter 2 Demand Filed:    17.07.1997    
IPC:
A61K 38/00 (2006.01), A61K 39/00 (2006.01), C07K 16/42 (2006.01), G01N 33/574 (2006.01)
Applicants: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION [US/US]; Intellectual Property Development, A144 ASTeCC Building, Lexington, KY 40506-0286 (US) (For All Designated States Except US).
CHATTERJEE, Malaya [US/US]; (US) (For US Only).
FOON, Kenneth, A. [US/US]; (US) (For US Only).
CHATTERJEE, Sunil, K. [US/US]; (US) (For US Only)
Inventors: CHATTERJEE, Malaya; (US).
FOON, Kenneth, A.; (US).
CHATTERJEE, Sunil, K.; (US)
Agent: POLIZZI, Catherine, M.; Morrison & Foerster L.L.P., 755 Page Mill Road, Palo Alto, CA 94304-1018 (US).
WRIGHT, Simon, Mark; J. A. Kemp & Co, 14 South Square, Gray's Inn, London WC1R 5LX (GB)
Priority Data:
08/575,762 20.12.1995 US
08/591,965 29.01.1996 US
08/766,350 13.12.1996 US
Title (EN) MURINE MONOCLONAL ANTI-IDIOTYPE ANTIBODY 11D10 AN METHODS OF USE THEREOF
(FR) ANTICORPS MONOCLONAL MURIN ANTI-IDIOTYPE 11D10 ET SES PROCEDES D' UTILISATION
Abstract: front page image
(EN)The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in mice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG-associated tumors.
(FR)L'invention concerne un anticorps monoclonal anti-idiotype 11D10 provoquant une réaction immunitaire contre un déterminant antigénique spécifique d'une mucine à poids moléculaire élevé de globule de matières grasses du lait maternel (HMFG), ainsi qu'un hybridome produisant 11D10. L'hybridome produisant 11D10 a été sélectionné au moyen de procédés spécifiques. 11D10 provoque une réaction immunitaire contre HMFG chez la souris, le lapin, le singe et chez les malades présentant des tumeurs évoluées associées à HMFG. L'invention concerne des compositions obtenues au moyen de séquences de polynucléotides codant les régions variables légères ou lourdes de l'anticorps monoclonal anti-idiotype 11D10, ainsi que des polypeptides codés par lesdites séquences. L'invention concerne également des compositions qu'on peut utiliser dans la détection ou le traitement de tumeurs associées à HMFG.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)