WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1997022696) UTROPHIN GENE EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/022696    International Application No.:    PCT/GB1996/003156
Publication Date: 26.06.1997 International Filing Date: 19.12.1996
Chapter 2 Demand Filed:    14.07.1997    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/47 (2006.01)
Applicants: MEDICAL RESEARCH COUNCIL [GB/GB]; 20 Park Crescent, London W1N 4AL (GB) (For All Designated States Except US).
TINSLEY, Jonathon, Mark [GB/GB]; (GB) (For US Only).
DAVIES, Kay, Elizabeth [GB/GB]; (GB) (For US Only)
Inventors: TINSLEY, Jonathon, Mark; (GB).
DAVIES, Kay, Elizabeth; (GB)
Agent: WALTON, Seán, M.; Mewburn Ellis, York House, 23 Kingsway, London WC2B 6HP (GB)
Priority Data:
9525962.8 19.12.1995 GB
9615797.9 26.07.1996 GB
9622174.2 24.10.1996 GB
Title (EN) UTROPHIN GENE EXPRESSION
(FR) EXPRESSION GENIQUE D'UTROPHINE
Abstract: front page image
(EN)Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic muscle phenotype in an animal model, indicating usefulness in treatment of muscular dystrophy. The nucleic acid and encoded polypeptides are also useful in screening for substances to modulate utrophin binding to actin and/or the dystrophin protein complex.
(FR)Acide nucléique à partir duquel peut être exprimé un polypeptide à fonction d'utrophine, en particulier des mini-gènes et des produits de recombinaison chimériques. Ladite expression réduit de manière importante la gravité du phénotype de muscle dystrophique chez un modèle animal, ce qui constitue une indication de son utilité dans le traitement de la dystrophie musculaire. Ledit acide nucléique et les polypeptides codés sont également utiles pour cribler des substances destinées à moduler la liaison de l'utrophine à l'actine et/ou au complexe protéinique de la dystrophine.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)