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Machine translation
1. (WO1997022630) SELECTIVE ALKYLATIONS OF CYCLODEXTRINS AT THE LEVELS OF MINIMAL EFFECTIVE BASICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/022630    International Application No.:    PCT/US1996/020029
Publication Date: 26.06.1997 International Filing Date: 18.12.1996
Chapter 2 Demand Filed:    09.06.1997    
IPC:
A61K 47/48 (2006.01), C07H 1/00 (2006.01), C08B 37/16 (2006.01)
Applicants: PITHA, Josef [US/US]; (US)
Inventors: PITHA, Josef; (US)
Agent: HENDRICKS, Glenna; P.O. Box 2509, Fairfax, VA 22031 (US)
Priority Data:
08/575,075 19.12.1995 US
Title (EN) SELECTIVE ALKYLATIONS OF CYCLODEXTRINS AT THE LEVELS OF MINIMAL EFFECTIVE BASICITY
(FR) ALKYLATIONS SELECTIVES DE CYCLODEXTRINES AUX NIVEAUX DE BASICITE EFFICACE MINIMALE
Abstract: front page image
(EN)By controlling basicity of the reaction, it is possible to alkylate preferentially the secondary hydroxyls of cyclodextrins. These hydroxyls surround the principal, wide, entry into the cyclodextrin cavity and, thus, their substitution by suitably chosen substituents can improve the formation of inclusion complexes. By methods of the invention, cyclodextrin derivatives substituted with fused 1,4-dioxane ring(s) can be obtained. If a reagent with one alkylating moiety is used, a mixture of ethers of cyclodextrin is formed. Using methods of this invention, up to 96 % of the substitution can be directed to the secondary hydroxyls.
(FR)En régulant la basicité de la réaction, il est possible d'effectuer de préférence l'alkylation des groupes hydroxyles secondaires de cyclodextrines. Ces groupes hydroxyles entourent l'entrée principale et large donnant accès à la cavité des cyclodextrines et, de cette manière, leur substitution par des substituants convenablement choisis peut améliorer la formation de complexes d'inclusion. Selon les procédés de l'invention, il est possible d'obtenir des dérivés de cyclodextrines substitués par des noyaux 1,4-dioxane condensés. Si l'on utilise un réactif doté d'une fraction alkylante, on forme un mélange d'éthers de cyclodextrine. Les procédés de cette invention permettent de diriger jusqu'à 96 % de la substitution sur les groupes hydroxyles secondaires.
Designated States: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)