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Machine translation
1. (WO1997022618) INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/022618    International Application No.:    PCT/US1996/020370
Publication Date: 26.06.1997 International Filing Date: 20.12.1996
Chapter 2 Demand Filed:    21.07.1997    
IPC:
A61K 38/00 (2006.01), C07K 5/02 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street, Cambridge, MA 02139-4242 (US)
Inventors: BEMIS, Guy, W.; (US).
DUFFY, John, P.; (US).
FRIDMAN, Wolf, Herman; (FR).
GOLEC, Julian, M., C.; (GB).
LIVINGSTON, David, J.; (US).
MULLICAN, Michael, D.; (US).
MURCKO, Mark, A.; (US).
ZELLE, Robert, E.; (US)
Agent: HALEY, James, F., Jr.; Fish & Neave, 1251 Avenue of the Americas, New York, NY 10020-1104 (US).
VOSSIUS & PARTNER; Siebertstrasse 4, D-81675 München (DE)
Priority Data:
08/575,648 20.12.1995 US
Title (EN) INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME
(FR) INHIBITEURS DE L'ENZYME CONVERTISSANT L'INTERLEUKINE-1$g(b)
Abstract: front page image
(EN)The present invention relates to novel classes of compounds which are inhibitors of interleukin-1$g(b) converting enzyme. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 and apoptosis-mediated diseases, including inflammatory diseases, autoimmune diseases, proliferative, infectious, and degenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
(FR)La présente invention se rapporte à de nouvelles classes de composés qui sont des inhibiteurs de l'enzyme convertissant l'interleukine-1$g(b) ('ICE'). Cette invention se rapporte également à des compositions pharmaceutiques comprenant ces composés. Ces composés et compositions pharmaceutiques sont notamment appropriés à l'inhibition de l'activité d'ICE et, par conséquent, peuvent être utilisés idéalement comme agents agissant contre l'interleukine-1 et les maladies induites par l'apoptose, y compris les maladies inflammatoires, les maladies auto-immunes, les maladies prolifératives, infectieuses et dégénératives. Cette invention se rapporte également à des procédés d'inhibition de l'activité d'ICE et à des procédés de traitement de maladies induites par l'interleukine-1 dans lesquels sont utilisés lesdits composés et compositions.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)