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Machine translation
1. (WO1997021811) NOVEL TYROSINE KINASE RECEPTORS AND LIGANDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/021811    International Application No.:    PCT/US1996/020696
Publication Date: 19.06.1997 International Filing Date: 13.12.1996
Chapter 2 Demand Filed:    02.07.1997    
IPC:
A61K 38/00 (2006.01), A61K 48/00 (2006.01), C07K 14/705 (2006.01), C07K 14/78 (2006.01), C07K 14/81 (2006.01), C07K 16/38 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, NY 10591-6707 (US) (For All Designated States Except US).
VALENZUELA, David, M. [CL/US]; (US) (For US Only).
GLASS, David, J. [US/US]; (US) (For US Only).
BOWEN, David, C. [US/US]; (US) (For US Only).
YANCOPOULOS, George, D. [US/US]; (US) (For US Only)
Inventors: VALENZUELA, David, M.; (US).
GLASS, David, J.; (US).
BOWEN, David, C.; (US).
YANCOPOULOS, George, D.; (US)
Agent: COBERT, Robert, J.; Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591 (US).
GOLDIN, Douglas, Michael; J.A. Kemp & Co., 14 South Square, Gray's Inn, London WC1R 5LX (GB)
Priority Data:
60/008,657 15.12.1995 US
08/644,271 10.05.1996 US
Title (EN) NOVEL TYROSINE KINASE RECEPTORS AND LIGANDS
(FR) NOUVEAUX RECEPTEURS DU TYPE TYROSINE KINASE ET LIGANDS
Abstract: front page image
(EN)The present invention provides for a gene, designated as musk, that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides for an isolated polypeptide which activates MuSK receptor. The invention further provides for a polypeptide which is functionally equivalent to the MuSK activating polypeptide. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the musk gene product. The present invention also provides for diagnostic and therapeutic methods based on molecules that activate MuSK.
(FR)L'invention concerne un gène appelé musk, qui code un nouveau récepteur du type tyrosine kinase exprimé à des niveaux élevés dans un muscle dénervé. Elle se rapporte encore à un polypeptide isolé qui active le récepteur MuSK ainsi qu'à un polypeptide qui est équivalent sur le plan fonctionnel au polypeptide activant MuSK. Elle porte aussi sur des systèmes de criblage qui peuvent être utilisés pour détecter et/ou mesurer les ligands qui se lient au produit génique musk et sur des méthodes diagnostiques et thérapeutiques basées sur les molécules activant MuSK.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)