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1. (WO1997021803) ALDOLASE CATALYTIC ANTIBODY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/021803    International Application No.:    PCT/US1996/020052
Publication Date: 19.06.1997 International Filing Date: 16.12.1996
Chapter 2 Demand Filed:    14.07.1997    
IPC:
C12N 9/00 (2006.01), C12N 9/88 (2006.01), C12P 7/26 (2006.01)
Applicants: THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road, La Jolla, CA 92037 (US)
Inventors: BARBAS, Carlos, F., III; (US).
LERNER, Richard, A.; (US).
WAGNER, Juergen; (CH)
Agent: LEWIS, Donald, G.; The Scripps Research Institute, 10550 North Torrey Pines Road, TPC-8, La Jolla, CA 92037 (US)
Priority Data:
08/573,415 15.12.1995 US
Title (EN) ALDOLASE CATALYTIC ANTIBODY
(FR) ANTICORP CATALYTIQUE ALDOLASE
Abstract: front page image
(EN)Antibodies that catalyse the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.
(FR)Des anticorps qui catalysent la réaction d'aldéhyde-alcool sont générés par immunisation par un composé réactif. Ce dernier piège, par covalence, un résidu de Lysine (Lys) dans la poche de liaison de l'anticorps, en assurant la formation d'un amide vinylogue stable, c'est-à-dire, un complexe anticorps covalent/haptène. Les anticorps catalytiques ainsi obtenus utilisent un mécanisme catalytique qui mime le mécanisme catalytique utilisé par les enzymes aldolases naturelles de classe I.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)