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Machine translation
1. (WO1997021691) THIAZOLE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/021691    International Application No.:    PCT/JP1996/003637
Publication Date: 19.06.1997 International Filing Date: 13.12.1996
Chapter 2 Demand Filed:    11.07.1997    
IPC:
C07D 277/28 (2006.01)
Applicants: KAKEN PHARMACEUTICAL CO., LTD. [JP/JP]; 28-8, Honkomagome 2-chome, Bunkyo-ku, Tokyo 113 (JP) (For All Designated States Except US).
NAKANO, Jun [JP/JP]; (JP) (For US Only).
MURAI, Satoshi [JP/JP]; (JP) (For US Only).
YAMAMOTO, Hiroshi [JP/JP]; (JP) (For US Only).
ICHIKAWA, Yoshihiro [JP/JP]; (JP) (For US Only).
OGAWA, Masaru [JP/JP]; (JP) (For US Only).
WATANUKI, Mitsuru [JP/JP]; (JP) (For US Only).
DEBUCHI, Kimie [JP/JP]; (JP) (For US Only).
NAKAMURA, Tsutomu [JP/JP]; (JP) (For US Only)
Inventors: NAKANO, Jun; (JP).
MURAI, Satoshi; (JP).
YAMAMOTO, Hiroshi; (JP).
ICHIKAWA, Yoshihiro; (JP).
OGAWA, Masaru; (JP).
WATANUKI, Mitsuru; (JP).
DEBUCHI, Kimie; (JP).
NAKAMURA, Tsutomu; (JP)
Priority Data:
7/347352 14.12.1995 JP
Title (EN) THIAZOLE DERIVATIVES
(FR) DERIVES THIAZOLE
Abstract: front page image
(EN)Thiazole derivatives of general formula (I) and salts thereof, exhibiting both leukotriene D¿4? and thromboxane A¿2? receptor antagonisms. In formula (I), X is carbonyl or sulfonyl; Y is carboxyl, C¿1?-C¿5? alkoxycarbonyl or 1H-tetrazol-5-yl; Z is C¿1?-C¿5? alkyl, C¿3?-C¿6? cycloalkyl or phenyl; W is C¿2?-C¿5? alkylene or 1,4-cyclohexylene, and R is optionally subsituted phenylsulfonylamino, phenylsulfonyl, N'-phenylthioureido or C¿1?-C¿5? alkylsulfonylamino.
(FR)Les dérivés thiazole représentés par la formule générale (I) et certains de leurs sels font preuve d'antagonisme aux récepteurs aussi bien du leucotriène D¿4? que de la thromboxane A¿2?. Dans cette formule générale, X est carbonyle ou sulfonyle; Y est carboxyle, alcoxycarbonyle C¿1?-C¿5? ou 1H-tétrazol-5-yle; Z est alkyle C¿1?-C¿5?, cycloalkyle C¿3?-C¿6? ou phényle; W est alkylène C¿2?-C¿5? ou 1,4-cycloxyhexylène, et R est phénylsulfonylamino, phénylsulfonyle, N'-phénylthiouréïdo ou alkylsulfonylamino C¿1?-C¿5? éventuellement substitués.
Designated States: AU, CA, CN, JP, KR, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)