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Machine translation
1. (WO1997021653) PROCESS FOR THE PREPARATION OF 9-DEAZAGUANINE DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/021653    International Application No.:    PCT/US1996/019556
Publication Date: 19.06.1997 International Filing Date: 12.12.1996
Chapter 2 Demand Filed:    26.06.1997    
IPC:
C07D 487/04 (2006.01)
Applicants: BIOCRYST PHARMACEUTICALS, INC. [US/US]; 2190 Parkway Lake Drive, Birmingham, AL 35244 (US) (For All Designated States Except US).
ELLIOTT, Arthur, J. [US/US]; (US) (For US Only).
WALSH, David, A. [US/US]; (US) (For US Only).
MORRIS, Philip, E. [US/US]; (US) (For US Only)
Inventors: ELLIOTT, Arthur, J.; (US).
WALSH, David, A.; (US).
MORRIS, Philip, E.; (US)
Agent: AMERNICK, Burton, A.; Pollock, Vande Sande & Priddy, Suite 800, 1990 M Street, N.W., Washington, DC 20036-3425 (US)
Priority Data:
Title (EN) PROCESS FOR THE PREPARATION OF 9-DEAZAGUANINE DERIVATIVES
(FR) PROCEDE DE PREPARATION DE DERIVES 9-DESAZAGUANINE
Abstract: front page image
(EN)Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound or a derivative of carbamimidoic acid to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.
(FR)On prépare des dérivés de la 9-désazaguanine en faisant réagir un aldéhyde ou une cétone avec un dialkylaminomalonate pour former l'énamine correspondante. On fait ensuite réagir l'énamine avec une base pour former un pyrrole cyclique. On fait réagir le pyrrole cyclique avec un composé ureique ou un dérivé de l'acide carbamimidoïque pour fournir un composé guanidino protégé. Le composé guanidino est converti en dérivé 9-désazaguanine par mise en réaction avec de l'acide trifluoroacétique ou avec un alcoxyde ou un hydroxyde suivi par une neutralisation avec un acide.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)