WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1997019951) NOVEL POLYMER SUPPORTS FOR NUCLEIC ACID SYNTHESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1997/019951    International Application No.:    PCT/US1996/019050
Publication Date: 05.06.1997 International Filing Date: 27.11.1996
Chapter 2 Demand Filed:    20.06.1997    
IPC:
C07H 21/00 (2006.01)
Applicants: HYBRIDON, INC. [US/US]; 620 Memorial Drive, Cambridge, MA 02139 (US)
Inventors: TANG, Jin-Yan; (US).
TANG, Jimmy, X.; (US)
Agent: KEOWN, Wayne, A.; Hale and Dorr, 60 State Street, Boston, MA 02109 (US)
Priority Data:
08/562,841 27.11.1995 US
Title (EN) NOVEL POLYMER SUPPORTS FOR NUCLEIC ACID SYNTHESIS
(FR) NOUVEAUX SUPPORTS EN POLYMERE POUR LA SYNTHESE DES ACIDES NUCLEIQUES
Abstract: front page image
(EN)The invention provides passivated organic polymer supports, processes for their preparation and processes for their use in oligonucleotide synthesis that allow for highly efficient solid phase synthesis of oligonucleotides. According to the invention, oligonucleotide synthesis is preferably carried out on an organic polymer support passivated by reaction with benzoic acid anhydride. The improved process reduces the amount of N-1 failure sequences.
(FR)L'invention concerne des supports en polymère organique passivés, ainsi que des procédés permettant leur préparation et leur utilisation pour la synthèse des acides nucléiques. Ils permettent de synthétiser des oligonucléotides en phase solide avec un rendement très élevé. Selon l'invention, on réalise de préférence la synthèse des oligonucléotides sur un support en polymère organique passivé par réaction avec l'anhydride d'acide benzoïque. Ce procédé amélioré diminue le nombre de perturbations au niveau de la séquence n-1.
Designated States: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TR, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)