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1. (WO1997019357) ASSAY FOR BLOOD CLOTTING FACTORS VIII AND IX
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019357 International Application No.: PCT/US1996/019275
Publication Date: 29.05.1997 International Filing Date: 22.11.1996
Chapter 2 Demand Filed: 10.06.1997
IPC:
C12Q 1/56 (2006.01) ,G01N 33/86 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
56
involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
86
involving blood coagulating time
Applicants:
OKLAHOMA MEDICAL RESEARCH FOUNDATION [US/US]; 825 N.E. 13th Street Oklahoma City, OK 73104, US (AllExceptUS)
MORRISSEY, James, H. [US/US]; US (UsOnly)
Inventors:
MORRISSEY, James, H.; US
Agent:
HANSEN, Eugenia, S. ; Sidley & Austin Suite 3400 717 North Harwood Dallas, TX 75201, US
Priority Data:
60/007,47422.11.1995US
Title (EN) ASSAY FOR BLOOD CLOTTING FACTORS VIII AND IX
(FR) ESSAI DE DOSAGE POUR LES FACTEURS DE COAGULATION SANGUINE VIII ET IX
Abstract:
(EN) An assay has been developed to detect the presence of blood clotting factors, including factors VIII and IX, utilizing mutated tissue factor. Mutated forms of wild type tissue factor as well as various forms of truncated tissue factor can be used. Preferably, substitutions of glutamine, alanine, glutamic acid, or combinations thereof are made at amino acid positions 165, 166 or 165 and 166. Various tissue factor mutants exhibit different extents of activity in supporting FVIII and FIX activation: Q165Q166 > A165A166 > E165E166.
(FR) Un essai de dosage a été mis au point pour détecter la présence de facteurs de coagulation sanguine, y compris les facteurs VIII et IX, utilisant des facteurs tissulaires mutés. Des formes mutées de facteurs tissulaires de type sauvage ainsi que diverses formes de facteurs tissulaires tronqués peuvent être utilisées. De préférence, des substitutions de glutamine, d'analine, d'acide glutamique ou de combinaisons de ceux-ci sont effectuées aux positions 165, 166 ou 165 et 166 des acides aminés. Divers mutants de facteurs tissulaires possèdent différentes ampleurs d'activités dans leur soutien à l'activation de FVIII et FIX: Q165Q166 > A165A166 > E165E166.
Designated States: AU, CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0862742JP2000500348CA2236155AU1997013286