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1. (WO1997019352) THERAPEUTIC AGENTS AND SCREENING METHOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1997/019352 International Application No.: PCT/EP1996/004913
Publication Date: 29.05.1997 International Filing Date: 11.11.1996
Chapter 2 Demand Filed: 04.04.1997
IPC:
G01N 33/50 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
NOVARTIS AG [CH/CH]; Schwarzwaldallee 215 CH-4058 Basel, CH (AllExceptUS)
SUSA SPRING, Mira [CH/CH]; CH (UsOnly)
Inventors:
SUSA SPRING, Mira; CH
Common
Representative:
NOVARTIS AG; Patent and Trademark Dept. Klybeckstrasse 141 CH-4002 Basle, CH
Priority Data:
95810728.622.11.1995EP
Title (EN) THERAPEUTIC AGENTS AND SCREENING METHOD
(FR) AGENTS THERAPEUTIQUES ET PROCEDE DE CRIBLAGE
Abstract:
(EN) Although fluoride is a potent stimulator of bone formation, it remains of questionable use as a therapeutic principle in view of its narrow therapeutic window, toxicity and its tendency to induce poor quality bone formation. We provide a method for screening candidate compounds which act to increase bone formation comprising assessing the activity of the compounds as G protein stimulators.
(FR) Bien que le fluorure soit un stimulateur puissant de la formation osseuse, on peut se questionner sur son utilisation en tant que principe thérapeutique, eu égard à son faible coefficient thérapeutique, à sa toxicité ainsi qu'à sa tendance à induire une formation osseuse de pauvre qualité. On décrit un procédé de criblage de composés candidats agissant pour accroître la formation osseuse, lequel consiste à évaluer l'activité de ces composés en tant que stimulateurs de la protéine G.
Designated States: AL, AU, BA, BB, BG, BR, CA, CN, CU, CZ, EE, GE, HU, IL, IS, JP, KP, KR, LC, LK, LR, LT, LV, MG, MK, MN, MX, NO, NZ, PL, RO, SG, SI, SK, TR, TT, UA, US, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, LS, MW, SD, SZ, UG)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1996076223